Recombinant Human SLAM/CD150 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM), also known as CD150, is the prototypic member of the SLAM subfamily of the CD2 protein family. CD2 family proteins function as adhesion molecules and modulators of the immune response (1). Mature human SLAM consists of a 217 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 77 aa cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM) (2). Within the ECD, human SLAM shares 58% and 56% aa sequence identity with mouse and rat SLAM, respectively. Alternative splicing generates two additional isoforms, with one showing a deletion in the cytoplasmic region (aa 299-335), and a second showing a deletion in the transmembrane domain (aa 234-263). It is expressed as a 75 kDa molecule, of which approximately 30 kDa represents N-linked carbohydrate (3). SLAM is expressed on T cells, B cells, thymocytes, macrophages, dendritic cells, platelets, and hematopoietic stem cells, and it is up-regulated on activated B cells and CD4⁺ and CD8⁺ T cells (2‑8). SLAM interacts homophilically with low affinity, and this interaction induces a Th0/Th1 phenotype in CD8⁺ T cells that is characterized by clonal expansion, production of IFN-gamma , and increased cytolytic activity (2, 3, 9-11). In addition, this interaction on CD4⁺ T cells promotes a Th2-type response, likely due to an association with the adaptor molecule SAP (4, 12). SLAM ligation also promotes an allergen-induced eosinophil and mast cell activation, NKT cell development, and the microbicidal response of macrophages to Gram negative bacteria (8, 13-15). In humans, SLAM functions as a cellular entry receptor for measles virus (16, 17).

Array 164-SL

• SLAM/CD150 Antibodies
• SLAM/CD150 Antibody Pair
• SLAM/CD150 Proteins
• SLAM/CD150 ELISA
• SLAM/CD150 Proteins and Enzymes