Recombinant Human sFRP-2 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein‑2 (sFRP‑2) belongs to a family of Wnt‑binding proteins with homology to the ligand‑binding domain of the Frizzled transmembrane Wnt receptors. The sFRP proteins are approximately 30‑35 kDa in size and contain an N-terminal Frizzled‑like domain with 10 conserved cysteines and a Netrin‑like C‑terminal domain (1, 2). Mature human sFRP‑2, also known as SARP‑1, SDF‑5, and FRP‑2, shares 99% aa sequence identity with mouse and rat sFRP‑2 (3). sFRP‑2 is widely expressed during embryogenesis and in the adult tissues including the eye, heart, lung, colon, intestine, smooth muscle, pancreas, prostate, testis, kidney, brain, teeth and joints, craniofacial mesenchyme, and preadipocytes (3‑6). Depending on the context, sFRP‑2 can exert either positive or negative effects on Wnt signaling (7‑9). It also inhibits BMP‑induced effects (8, 10). sFRP‑2 can be incorporated into the extracellular matrix through interactions with Fibronectin and Integrin alpha 5 beta 1 (11). sFRP‑2 plays a variety of roles during tissue morphogenesis including inhibition of the planar cell polarity pathway and myoblast and osteoblast differentiation (8, 10, 12, 13). sFRP‑2 is also expressed in multiple myeloma and glioma in which it promotes tumorigenicity (10, 14). At physiological concentrations sFRP‑2 enhances BMP‑1 mediated proteolysis of Pro‑Collagen I, whereas at higher concentrations it inhibits BMP‑1 activity (15, 16). This difference is significant considering that sFRP‑2 is up‑regulated in fibrotic areas of the heart following myocardial infarction (15, 16). Elevated levels of sFRP‑2 then promote the recovery of cardiac function by reducing collagen deposition, remodeling, and calcification and by promoting the engraftment of mesenchymal stem cells into the heart (8, 15).

We have publications tested in 3 confirmed species: Human, Mouse, N/A.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 9 of 9.

Publications using 6838-FR	Applications	Species
Hamida, OB;Kim, MK;Kwack, MH; The role of dexamethasone in mediating the contradictory effects of Wnt antagonists SFRP2 and SFRP3 on human hair follicle growth Scientific reports 2023-10-02 [PMID: 37783752] (Bioassay, Human)	Bioassay	Human
Cohen, ML;Brumwell, AN;Ho, TC;Montas, G;Golden, JA;Jones, KD;Wolters, PJ;Wei, Y;Chapman, HA;Le Saux, CJ; A fibroblast-dependent TGF?1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis bioRxiv : the preprint server for biology 2023-08-04 [PMID: 37577522] (Bioassay, Human)	Bioassay	Human
YC Hsueh, RE Pratt, VJ Dzau, CP Hodgkinson Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2 Scientific Reports, 2023-03-09;13(1):3920. 2023-03-09 [PMID: 36894665] (Bioassay, Human)	Bioassay	Human
P Jayabal, F Zhou, X Ma, KM Bondra, B Blackman, ST Weintraub, Y Chen, P Chévez-Bar, PJ Houghton, B Gallie, Y Shiio Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma Cell Reports, 2023-02-10;42(2):112103. 2023-02-10 [PMID: 36773293] (Bioassay, N/A)	Bioassay	N/A
JK Ledwon, EE Vaca, CC Huang, LJ Kelsey, JL McGrath, J Topczewski, AK Gosain, JM Topczewska Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching Journal of Cellular and Molecular Medicine, 2022-01-12;0(0):. 2022-01-12 [PMID: 35019227] (Bioassay, Human)	Bioassay	Human
G Liu, T Yan, X Li, J Sun, B Zhang, H Wang, Y Zhu Daam1 activates RhoA to regulate Wnt5a?induced glioblastoma cell invasion Oncol. Rep., 2017-12-01;0(0):. 2017-12-01 [PMID: 29207169] (Bioassay, Human)	Bioassay	Human
A Zhang, T Yan, K Wang, Z Huang, J Liu PI3K? isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration Cancer Cell Int., 2017-02-14;17(0):27. 2017-02-14 [PMID: 28289332] (Bioassay, Human)	Bioassay	Human
Kim M, Han J, Kim J, Park T, Kang H Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders. J Invest Dermatol, 2016-01-01;136(1):236-44. 2016-01-01 [PMID: 26763443] (Bioassay, Human)	Bioassay	Human
Carthy J, Engstrom U, Heldin C, Moustakas A Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling. J Cell Biochem, 2015-09-22;117(4):938-45. 2015-09-22 [PMID: 26369756] (Bioassay, Mouse)	Bioassay	Mouse

Array 6838-FR

• sFRP-2 Antibodies
• sFRP-2 ELISA Kits
• sFRP-2 Lysate
• sFRP-2 Proteins and Enzymes