Recombinant Human PA28 Activator alpha Subunit Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Proteasome Activator 28 (PA28) Regulatory Complex, also known as the 11S Regulatory (REG) Complex, is a ring-shaped, multimeric, ATP-independent regulatory complex that can bind to one or both ends of the 20S Proteasome or 20S Immunoproteasome (1,2). The PA28 Regulatory Complex stimulates the proteasome to hydrolyze small peptides, but not ubiquitinated proteins, for the production of peptides for MHC class I antigen presentation (3-7). Three PA28 Regulatory Complex subunits, alpha, beta, and gamma, have been identified and can oligomerize to form the PA28 Regulatory Complex (8-10). While the expression of the PA28 alpha and beta subunits are induced by IFN-gamma, the PA28 gamma subunit is not significantly affected (11,12).  In vivo, PA28 alpha forms hetero-heptamers or -hexamers with PA28 beta (13-15). PA28 alpha can also form active homo-heptamers in vitro and can be used to activate the 20S Proteasome (3,16). In addition to regulating production of MHC class I antigens, PA28 alpha may protect against oxidative stress (17).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Enzyme Assay.

Showing Publication 1 - 1 of 1.

Publication using E-381	Applications	Species
Li H, O'Donoghue A, van der Linden W, Xie S, Yoo E, Foe I, Tilley L, Craik C, da Fonseca P, Bogyo M Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature, 2016-02-11;530(7589):233-6. 2016-02-11 [PMID: 26863983] (Enzyme Assay, Human)	Enzyme Assay	Human

Array E-381

• PA28 Activator alpha Subunit/PSME1 Antibodies
• PA28 Activator alpha Subunit/PSME1 Lysate
• PA28 Activator alpha Subunit/PSME1 Protein
• PA28 Activator alpha Subunit/PSME1 Proteins and Enzyme