Recombinant Human MICB His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Major Histocompatibility Complex Class I Chain-related Gene B (MICB) is a transmembrane glycoprotein that functions as a ligand for human Natural-Killer Group 2 Member D (NKG2D) (1). MICB, along with the highly related MICA, are members of the non-classical MHC class I family. Similar to classical MHC class I proteins, MICB contains three Ig-like domains ( alpha 1, alpha 2, and alpha 3) in the extracellular domain (ECD), a transmembrane segment, and a carboxy-terminal cytoplasmic tail (2). The genes encoding MICA and MICB are found within the MHC on the short arm of human chromosome 6 and occur in most mammalian species but are absent from mouse and rat (2-4). Despite structural similarities, MICA/B only share ~27% amino acid (aa) identity with human MHC class I proteins (3). Both MICA and MICB display a significant degree of polymorphism within the ECD and this enables them to be reconfigured and bind with NKG2D rather than binding with beta 2-microglobulin (4, 5). Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells (6, 7). MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response (2, 8-11). Inhibition of MICA/B shedding through targeted antibodies allows anti-tumor immunity to be retained (12).

Array 10431-MB

• MICB Antibodies
• MICB Antibody Pair
• MICB ELISA Kit
• MICB Lysate
• MICB Proteins
• MICB ELISA
• MICB Proteins and Enzymes