Recombinant Human LAR Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PTPRF (Receptor-type tyrosine-protein phosphatase F), also called LAR (Leukocyte common antigen related), is a 212 kDa single-pass type I membrane protein that is a member of the protein tyrosine phosphatase (PTP) family and the receptor class 2A subfamily (1). Human LAR cDNA encodes 1,907 amino acids (aa) including a 29 aa signal sequence, a 1234 aa extracellular region with six potential N-glycosylation sites, a 21 aa transmembrane sequence, and a 623 aa cytoplasmic domain (1). An 1,898 aa isoform appears from alternative splicing; it is missing aa 772 to 780 (1). Human LAR shares a 95% aa sequence identity with mouse and rat LAR. LARs have been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling (2). An increased expression level of LARs have been found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance (3). LARs have been identified as novel ligands of SALM5/LRFN-5 that mediates SALM5/LRFN-5 dependent presynaptic differentiation in a splicing- dependent manner. SALM5/LRFN-5 interacts directly with the Ig domain of LAR family receptor protein tyrosine phosphatases. The postsynaptic SALM5/LRFN-5 promotes synapse development by trans-synaptically interacting with presynaptic LARs which is important for the regulation of excitatory synaptic strength (4). Clinically, LAR has been shown down-regulated in cancers and its up-regulation is associated with better clinical outcomes (5).

Array 9377-PF

• LAR/PTPRF Antibodies
• LAR/PTPRF Protein
• LAR/PTPRF Proteins and Enzyme