Recombinant Human Inhibin A Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Inhibin A is a member of the TGF-beta superfamily of proteins (1). Mature Inhibin A is a disulfide-linked dimer composed of alpha and beta  subunits (1). Inhibin A shares a common alpha  subunit with the closely related protein Inhibin B but has a unique beta  subunit ( beta A) (2, 3). The mature alpha  subunit of human Inhibin A has a predicted molecular weight of 18 kDa and shares 80% amino acid (aa) sequence identity with the mouse and rat orthologs (2, 4). The mature beta  subunit of this human protein has a predicted molecular weight of 13 kDa and shares 100% aa sequence identity with the mouse and rat orthologs. Inhibin binds and antagonizes ActRIIA and ActRIIB in complex with the TGF-beta RIII and/or IGSF1 co-receptors and subsequently acts to suppress Activin-induced Follicle Stimulating Hormone (FSH) secretion (1, 5-7). Inhibins are produced by gonadal cells in both males and females (8). They are thought to be involved in the regulation of gametogenesis, and embryonic and fetal development (8, 9). Elevated concentrations of Inhibins are associated with pregnancy, preeclampsia, and ovarian cancer, and Inhibin A levels are typically measured during prenatal screening for Down’s syndrome (10-14).

Array 8506-AB

• Inhibin alpha Antibodies
• Inhibin alpha ELISA Kit
• Inhibin alpha Lysate
• Inhibin alpha Protein
• Inhibin alpha Proteins and Enzymes