Recombinant Human IL-12 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and murine IL-12 share 70% and 60% amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system.

IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma  inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma  gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL‑12, produced by macrophages in response to infectious agents, is a central mediator of the cell-mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS.

We have publications tested in 5 confirmed species: Human, Mouse, N/A, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Rhesus Macaque.

We have publications tested in 7 applications: Bioassay, CAR-T (Bioassay), Cell Culture, ELISA (Control), ELISA (Specificity Testing), ELISA (Standard), Stimulation.

Showing Publications 1 - 10 of 130. Show All 130 Publications. Collapse Publications.

Publications using 219-IL/CF	Applications	Species
ACH Szeto, ACF Ferreira, J Mannion, PA Clark, M Sivasubram, MWD Heycock, A Crisp, HE Jolin, P Kozik, MD Knolle, ANJ McKenzie An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity Nature Immunology, 2022-12-22;24(1):123-135. 2022-12-22 [PMID: 36550322] (Bioassay, Human)	Bioassay	Human
E Cruz-Loren, NP Ramirez, J Lee, S Pandhe, L Wang, J Hernandez-, AM Spivak, V Planelles, T Petersen, MK Jain, ED Martinez, I D'Orso Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity Viruses, 2022-10-18;14(10):. 2022-10-18 [PMID: 36298843] (Bioassay, Human)	Bioassay	Human
AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human)	Stimulation	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)	Cell Culture	Human
G Carbotti, B Dozin, S Martini, C Giordano, F Scordamagl, M Croce, G Filaci, S Ferrini, M Fabbi IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells Cancers, 2021-08-09;13(16):. 2021-08-09 [PMID: 34439164] (Bioassay, Human)	Bioassay	Human
K Jamal Jame, WJ Gallert, SD Yanik, S Panek, J Kronsbein, D Jungck, A Koch, J Knobloch Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD International Journal of Molecular Sciences, 2021-07-02;22(13):. 2021-07-02 [PMID: 34281240] (Bioassay, Human)	Bioassay	Human
M Ogishi, R Yang, C Aytekin, D Langlais, M Bourgey, T Khan, FA Ali, M Rahman, OM Delmonte, M Chrabieh, P Zhang, C Gruber, SJ Pelham, AN Spaan, J Rosain, WT Lei, S Drutman, MD Hellmann, MK Callahan, M Adamow, P Wong, JD Wolchok, G Rao, CS Ma, Y Nakajima, T Yaguchi, K Chamoto, SC Williams, JF Emile, F Rozenberg, MS Glickman, F Rapaport, G Kerner, G Allington, I Tezcan, D Cagdas, FO Hosnut, F Dogu, A Ikinciogul, VK Rao, L Kainulaine, V Béziat, J Bustamante, S Vilarinho, RP Lifton, B Boisson, L Abel, D Bogunovic, N Marr, LD Notarangel, SG Tangye, T Honjo, P Gros, S Boisson-Du, JL Casanova Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child Nature Medicine, 2021-06-28;0(0):. 2021-06-28 [PMID: 34183838] (Bioassay, Human)	Bioassay	Human
ML Chen, X Huang, H Wang, C Hegner, Y Liu, J Shang, A Eliason, H Diao, H Park, B Frey, G Wang, SA Mosure, LA Solt, DJ Kojetin, A Rodriguez-, DA Schady, CT Weaver, ME Pipkin, DD Moore, MS Sundrud CAR directs T cell adaptation to bile acids in the small intestine Nature, 2021-04-07;0(0):. 2021-04-07 [PMID: 33828301] (Bioassay, Mouse)	Bioassay	Mouse
E Kidzeru, MA Gasper, D Shao, PT Edlefsen, N Lejarcegui, E Havyariman, K Urdahl, S Gantt, H Horton, H Jaspan, A Gervassi Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants Journal of leukocyte biology, 2021-01-21;0(0):. 2021-01-21 [PMID: 33477200] (Bioassay, Human)	Bioassay	Human
S Watanabe, M Fujino, Y Saito, N Ahmed, H Sato, C Sugimoto, T Okamura, K Hanaki, EE Nakayama, T Shioda, K Matsushima, AA Ansari, F Villinger, K Mori Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions J. Immunol., 2020-08-03;0(0):. 2020-08-03 [PMID: 32747501] (Bioassay, Rhesus Macaque)	Bioassay	Rhesus Macaque
MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 2020-05-29;0(0):. 2020-05-29 [PMID: 32651134] (Bioassay, Human)	Bioassay	Human
J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Human)	Bioassay	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
Y Hu, H Liu, C Fang, C Li, F Xhyliu, H Dysert, J Bodo, G Habermehl, BE Russell, W Li, M Chappell, X Jiang, SL Ondrejka, ED Hsi, JP Maciejewsk, Q Yi, KC Anderson, NC Munshi, G Ao, JN Valent, J Lin, J Zhao Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma Cancer Res., 2020-03-19;0(0):. 2020-03-19 [PMID: 32193289] (Cell Culture, Human)	Cell Culture	Human
JU Shin, HE Abaci, L Herron, Z Guo, B Sallee, A Pappalardo, J Jackow, EHC Wang, Y Doucet, AM Christiano Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing Sci Rep, 2020-03-05;10(1):4123. 2020-03-05 [PMID: 32139717] (Cell Culture, Human)	Cell Culture	Human
UI Wu, KN Olivier, DB Kuhns, DL Fink, EP Sampaio, AM Zelazny, SJ Shallom, BE Marciano, MS Lionakis, SM Holland Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production Open Forum Infect Dis, 2019-11-28;6(12):ofz484. 2019-11-28 [PMID: 31807607] (Bioassay, Human)	Bioassay	Human
R Khoshnevis, N Nekooei-Ma, C Klein, D Kotlarz, M Behnam, V Ostadi, M Yaran, A Rezaei, R Sherkat IL-12Rbeta1 deficiency corresponding to concurrency of two diseases, mendelian susceptibility to mycobacterial disease and Crohn's disease J Clin Tuberc Other Mycobact Dis, 2019-09-20;17(0):100123. 2019-09-20 [PMID: 31788565] (Bioassay, Human)	Bioassay	Human
AC Pecher, F Kettemann, E Asteriti, H Schmid, S Duerr-Stoe, H Keppeler, JC Henes, R Klein, C Hinterleit, KA Secker, C Schneidawi, L Kanz, D Schneidawi Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis Arthritis Res. Ther., 2019-10-15;21(1):212. 2019-10-15 [PMID: 31615552] (Bioassay, Human)	Bioassay	Human
T Hofland, I de Weerdt, H Ter Burg, R de Boer, S Tannheimer, SH Tonino, AP Kater, E Eldering Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes J. Immunol., 2019-09-11;0(0):. 2019-09-11 [PMID: 31511358] (Bioassay, Human)	Bioassay	Human
H Wang, L Shen, X Sun, F Liu, W Feng, C Jiang, X Chu, X Ye, C Jiang, Y Wang, P Zhang, M Zang, D Zhu, Y Bi Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity Nat Commun, 2019-07-22;10(1):3254. 2019-07-22 [PMID: 31332184] (Cell Culture, Human)	Cell Culture	Human
JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263279] (Cell Culture, Human)	Cell Culture	Human
J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1 EBioMedicine, 2019-04-02;0(0):. 2019-04-02 [PMID: 30952614] (Bioassay, Human)	Bioassay	Human
T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)	Bioassay	Human
LD Uppendahl, M Felices, L Bendzick, C Ryan, B Kodal, P Hinderlie, KLM Boylan, APN Skubitz, JS Miller, MA Geller Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells Gynecol. Oncol., 2019-01-15;0(0):. 2019-01-15 [PMID: 30658847] (Bioassay, Human)	Bioassay	Human
P Gruarin, S Maglie, M De Simone, B Häringer, C Vasco, V Ranzani, R Bosotti, JS Noddings, P Larghi, F Facciotti, ML Sarnicola, M Martinovic, MC Crosti, M Moro, RL Rossi, ME Bernardo, F Caprioli, F Locatelli, G Rossetti, S Abrignani, M Pagani, J Geginat Eomesodermin controls a unique differentiation program in human IL-10 and IFN-? co-producing regulatory T-cells Eur. J. Immunol., 2018-11-29;0(0):. 2018-11-29 [PMID: 30431161] (Bioassay, Human)	Bioassay	Human
AA Throm, JB Alinger, JT Pingel, AL Daugherty, LM Pachman, AR French Dysregulated NK cell PLC?2 signaling and activity in juvenile dermatomyositis JCI Insight, 2018-11-15;3(22):. 2018-11-15 [PMID: 30429375] (Bioassay, Human)	Bioassay	Human
V Lagou, JE Garcia-Per, I Smets, L Van Horebe, M Vandebergh, L Chen, K Mallants, T Prezzemolo, K Hilven, S Humblet-Ba, M Moisse, P Van Damme, G Boeckxstae, P Bowness, B Dubois, J Dooley, A Liston, A Goris Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators Cell Rep, 2018-10-16;25(3):798-810.e6. 2018-10-16 [PMID: 30332657] (Bioassay, Human)	Bioassay	Human
JC Yu, G Lin, JJ Field, J Linden Induction of antiinflammatory purinergic signaling in activated human iNKT cells JCI Insight, 2018-09-06;3(17):. 2018-09-06 [PMID: 30185656] (Bioassay, Human)	Bioassay	Human
P Garnier, R Mummery, MJ Forster, B Mulloy, RV Gibbs, CC Rider The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit Cytokine, 2018-05-10;110(0):159-168. 2018-05-10 [PMID: 29753267] (Bioassay, Human)	Bioassay	Human
C Enerbäck, C Sandin, S Lambert, M Zawistowsk, PE Stuart, D Verma, LC Tsoi, RP Nair, A Johnston, JT Elder The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells Sci Rep, 2018-05-04;8(1):7043. 2018-05-04 [PMID: 29728633] (Bioassay, Human)	Bioassay	Human
Q Huang, M Huang, F Meng, R Sun Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment Cell. Mol. Immunol., 2018-04-08;0(0):. 2018-04-08 [PMID: 29628497] (Bioassay, Human)	Bioassay	Human
KS Burrack, MA Huggins, E Taras, P Dougherty, CM Henzler, R Yang, S Alter, EK Jeng, HC Wong, M Felices, F Cichocki, JS Miller, GT Hart, AJ Johnson, SC Jameson, SE Hamilton Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells Immunity, 2018-04-03;0(0):. 2018-04-03 [PMID: 29625893] (Cell Culture, Human)	Cell Culture	Human
L Golden-Mas, RH McMahan, MS Kriss, AL Kilgore, L Cheng, RJ Dran, A Wieland, HR Rosen Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun, 2018-03-01;2(4):364-375. 2018-03-01 [PMID: 29619416] (Bioassay, Human)	Bioassay	Human
S Sugita, K Makabe, Y Iwasaki, S Fujii, M Takahashi Natural Killer Cell Inhibition by HLA-E Molecules on Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., 2018-04-01;59(5):1719-1731. 2018-04-01 [PMID: 29610856] (Bioassay, Human)	Bioassay	Human
MC Neidert, DJ Kowalewski, M Silginer, K Kapolou, L Backert, LK Freudenman, JK Peper, A Marcu, SS Wang, JS Walz, F Wolpert, HG Rammensee, R Henschler, K Lamszus, M Westphal, P Roth, L Regli, S Stevanovi?, M Weller, G Eisele The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy Acta Neuropathol., 2018-03-20;0(0):. 2018-03-20 [PMID: 29557506] (Bioassay, Human)	Bioassay	Human
JJ Gilchrist, A Rautanen, BP Fairfax, TC Mills, V Naranbhai, H Trochet, M Pirinen, E Muthumbi, S Mwarumba, P Njuguna, N Mturi, CL Msefula, EN Gondwe, JM MacLennan, SJ Chapman, ME Molyneux, JC Knight, CCA Spencer, TN Williams, CA MacLennan, JAG Scott, AVS Hill Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4 Nat Commun, 2018-03-09;9(1):1014. 2018-03-09 [PMID: 29523850] (Bioassay, Human)	Bioassay	Human
JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018-03-01;0(0):. 2018-03-01 [PMID: 29496671] (Bioassay, Human)	Bioassay	Human
AW Clarke, L Poulton, D Shim, D Mabon, D Butt, M Pollard, V Pande, J Husten, J Lyons, C Tian, AG Doyle An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease MAbs, 2018-03-05;0(0):1-43. 2018-03-05 [PMID: 29436901] (Bioassay, Human)	Bioassay	Human
T Oth, THPM Habets, WTV Germeraad, MI Zonneveld, GMJ Bos, J Vanderloch Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-? BMC Immunol., 2018-02-13;19(1):8. 2018-02-13 [PMID: 29433450] (Bioassay, Human)	Bioassay	Human
M Felices, AJ Lenvik, R McElmurry, S Chu, P Hinderlie, L Bendzick, MA Geller, J Tolar, BR Blazar, JS Miller Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415897] (Bioassay, Human)	Bioassay	Human
M Najar, M Fayyad-Kaz, N Meuleman, D Bron, H Fayyad-Kaz, L Lagneaux Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation J Cell Commun Signal, 2018-01-19;0(0):. 2018-01-19 [PMID: 29350342] (Bioassay, Human)	Bioassay	Human
S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo A functional DC cross talk promotes human ILC homeostasis in humanized mice Blood Adv, 2017-04-06;1(10):601-614. 2017-04-06 [PMID: 29296702] (Human)		Human
A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 2017-03-30;1(10):577-589. 2017-03-30 [PMID: 29296700] (Human)		Human
Y Hijikata, T Okazaki, Y Tanaka, M Murahashi, Y Yamada, K Yamada, A Takahashi, H Inoue, J Kishimoto, Y Nakanishi, Y Oda, Y Nakamura, K Tani A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors PLoS ONE, 2018-01-02;13(1):e0187878. 2018-01-02 [PMID: 29293510] (Bioassay, Human)	Bioassay	Human
L Miao, S Zhan, J Liu Interleukin-12-mediated expression of matrix metalloproteinases in human periodontal ligament fibroblasts involves in NF-kappaB activation Biosci. Rep., 2017-11-21;0(0):. 2017-11-21 [PMID: 29054963] (Bioassay, Human)	Bioassay	Human
E Briend, GJ Ferguson, M Mori, G Damera, K Stephenson, NA Karp, S Sethi, CK Ward, MA Sleeman, JS Erjefält, DK Finch IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD Respir. Res., 2017-08-22;18(1):159. 2017-08-22 [PMID: 28830544] (Bioassay, Human)	Bioassay	Human
MS Longhi, M Vuerich, A Kalbasi, JE Kenison, A Yeste, E Csizmadia, B Vaughn, L Feldbrugge, S Mitsuhashi, B Wegiel, L Otterbein, A Moss, FJ Quintana, SC Robson Bilirubin suppresses Th17 immunity in colitis by upregulating CD39 JCI Insight, 2017-05-04;2(9):. 2017-05-04 [PMID: 28469075] (Bioassay, Human)	Bioassay	Human
C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations JCI Insight, 2017-03-09;2(5):e91127. 2017-03-09 [PMID: 28289717] (Bioassay, Human)	Bioassay	Human
H Tsukamoto, K Fujieda, M Hirayama, T Ikeda, A Yuno, K Matsumura, D Fukuma, K Araki, H Mizuta, H Nakayama, S Senju, Y Nishimura Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression Cancer Res, 2017-02-24;0(0):. 2017-02-24 [PMID: 28235765] (Bioassay, Human)	Bioassay	Human
H Jensen, SY Chen, L Folkersen, GP Nolan, LL Lanier EBI3 regulates the NK cell response to mouse cytomegalovirus infection Proc. Natl. Acad. Sci. U.S.A, 2017-01-31;0(0):. 2017-01-31 [PMID: 28143936] (Bioassay, Human)	Bioassay	Human
A Jud, M Kotur, C Berger, C Gysin, D Nadal, A Lünemann Tonsillar CD56brightNKG2A+ NK cells restrict primary Epstein-Barr virus infection in B cells via IFN-? Oncotarget, 2017-01-24;8(4):6130-6141. 2017-01-24 [PMID: 28008151] (Bioassay, Human)	Bioassay	Human
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML Mol Ther Methods Clin Dev, 2016-12-07;3(0):16074. 2016-12-07 [PMID: 27933304] (ELISA (Control), Human)	ELISA (Control)	Human
Roybal K, Williams J, Morsut L, Rupp L, Kolinko I, Choe J, Walker W, McNally K, Lim W Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell, 2016-09-29;167(2):419-432.e16. 2016-09-29 [PMID: 27693353] (CAR-T (Bioassay), Human)	CAR-T (Bioassay)	Human
I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia Haematologica, 2016-08-04;101(11):e461-e464. 2016-08-04 [PMID: 27662009] (Bioassay, Human)	Bioassay	Human
Y Wang, CS Ma, Y Ling, A Bousfiha, Y Camcioglu, S Jacquot, K Payne, E Crestani, R Roncagalli, A Belkadi, G Kerner, L Lorenzo, C Deswarte, M Chrabieh, E Patin, QB Vincent, I Müller-Fle, B Fleckenste, F Ailal, L Quintana-M, S Fraitag, MA Alyanakian, M Leruez-Vil, C Picard, A Puel, J Bustamante, S Boisson-Du, M Malissen, B Malissen, L Abel, A Hovnanian, LD Notarangel, E Jouanguy, SG Tangye, V Béziat, JL Casanova Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations J. Exp. Med., 2016-09-19;213(11):2413-2435. 2016-09-19 [PMID: 27647349] (Bioassay, Human)	Bioassay	Human
Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo PLoS Pathog, 2016-08-03;12(8):e1005788. 2016-08-03 [PMID: 27487232] (Bioassay, Human)	Bioassay	Human
Burak Dura Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture Proc Natl Acad Sci USA, 2016-06-14;0(0):. 2016-06-14 [PMID: 27303033] (Bioassay, Human)	Bioassay	Human
SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nat Immunol, 2016-04-25;0(0):. 2016-04-25 [PMID: 27111145] (Bioassay, Human)	Bioassay	Human
Chai S, Yap Y, Foo Y, Yap L, Ponniah S, Teo S, Cheong S, Patel V, Lim K Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLoS ONE, 2015-11-04;10(11):e0130464. 2015-11-04 [PMID: 26536470] (Bioassay, Human)	Bioassay	Human
Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, Nakashima T, Kajihara I, Makino K, Makino T, Fukushima S, Ihn H EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin. J Immunol, 2015-09-09;195(8):3565-73. 2015-09-09 [PMID: 26355156] (Bioassay, Human)	Bioassay	Human
Heinonen M, Laine A, Soderhall C, Gruzieva O, Rautio S, Melen E, Pershagen G, Lahdesmaki H, Knip M, Ilonen J, Henttinen T, Kere J, Lahesmaa R GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy. J Immunol, 2015-05-11;194(12):5885-94. 2015-05-11 [PMID: 25964488] (Bioassay, Human)	Bioassay	Human
Wilson R, Ives M, Rao G, Lau A, Payne K, Kobayashi M, Arkwright P, Peake J, Wong M, Adelstein S, Smart J, French M, Fulcher D, Picard C, Bustamante J, Boisson-Dupuis S, Gray P, Stepensky P, Warnatz K, Freeman A, Rossjohn J, McCluskey J, Holland S, Casanova J, Uzel G, Ma C, Tangye S, Deenick E STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med, 2015-05-04;212(6):855-64. 2015-05-04 [PMID: 25941256] (Bioassay, Human)	Bioassay	Human
Jacomet F, Cayssials E, Basbous S, Levescot A, Piccirilli N, Desmier D, Robin A, Barra A, Giraud C, Guilhot F, Roy L, Herbelin A, Gombert J Evidence for eomesodermin-expressing innate-like CD8(+) KIR/NKG2A(+) T cells in human adults and cord blood samples. Eur J Immunol, 2015-05-20;45(7):1926-33. 2015-05-20 [PMID: 25903796] (Bioassay, Human)	Bioassay	Human
Ranzani , Valeria, Rossetti , Grazisa, Panzeri , Ilaria, Arrigoni , Alberto, Bonnal , Raoul J, Curti , Serena, Gruarin , Paola, Provasi , Elena, Sugliano , Elisa, Marconi , Maurizio, De Francesco , Raffaele, Geginat , Jens, Bodega , Beatrice, Abrignani , Sergio, Pagani , Massimil The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol, 2015-01-26;16(3):318-25. 2015-01-26 [PMID: 25621826] (Bioassay, Human)	Bioassay	Human
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human)	Bioassay	Human
Moore C, Cui Q, Warsi N, Durafourt B, Zorko N, Owen D, Antel J, Bar-Or A Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol, 2014-12-10;194(2):761-72. 2014-12-10 [PMID: 25505283] (Bioassay, Human)	Bioassay	Human
Arber C, Feng X, Abhyankar H, Romero E, Wu M, Heslop H, Barth P, Dotti G, Savoldo B Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest, 2014-11-21;125(1):157-68. 2014-11-21 [PMID: 25415440] (Bioassay, Human)	Bioassay	Human
Lam , Sharon, Sung , Julia, Cruz , Conrad, Castillo-Caro , Paul, Ngo , Minhtran, Garrido , Carolina, Kuruc , Joann, Archin , Nancie, Rooney , Cliona, Margolis , David, Bollard , Catherin Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 2014-11-04;23(2):387-95. 2014-11-04 [PMID: 25366030] (Bioassay, Human)	Bioassay	Human
Mohnle P, Schutz S, van der Heide V, Hubner M, Luchting B, Sedlbauer J, Limbeck E, Hinske L, Briegel J, Kreth S MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon. Eur J Immunol, 2014-11-27;45(1):260-72. 2014-11-27 [PMID: 25308712] (Bioassay, Human)	Bioassay	Human
Kylaniemi M, Kaukonen R, Myllyviita J, Rasool O, Lahesmaa R The regulation and role of c-FLIP in human Th cell differentiation. PLoS ONE, 2014-07-14;9(7):e102022. 2014-07-14 [PMID: 25019384] (Bioassay, Human)	Bioassay	Human
Duhen T, Campbell D IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol, 2014-06-02;193(1):120-9. 2014-06-02 [PMID: 24890729] (Bioassay, Human)	Bioassay	Human
Touzot M, Grandclaudon M, Cappuccio A, Satoh T, Martinez-Cingolani C, Servant N, Manel N, Soumelis V Combinatorial flexibility of cytokine function during human T helper cell differentiation. Nat Commun, 2014-05-28;5(0):3987. 2014-05-28 [PMID: 24865484] (Bioassay, Human)	Bioassay	Human
Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-05-08;124(6):2513-22. 2014-05-08 [PMID: 24812667] (Bioassay, Human)	Bioassay	Human
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Bioassay, Human)	Bioassay	Human
Mavropoulos A, Bogdanos D, Liaskos C, Orfanidou T, Simopoulou T, Zafiriou E, Sakkas L, Rigopoulou E Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases. J Immunol Res, 2014-02-03;2014(0):671431. 2014-02-03 [PMID: 24741615] (Bioassay, Human)	Bioassay	Human
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol, 2014-03-21;134(9):2351-60. 2014-03-21 [PMID: 24658504] (Bioassay, Human)	Bioassay	Human
Zou Y, Li F, Hou W, Sampath P, Zhang Y, Thorne S Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells. Br J Cancer, 2014-03-18;110(8):1992-9. 2014-03-18 [PMID: 24642619] (Bioassay, Human)	Bioassay	Human
Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog, 2014-03-06;10(3):e1003936. 2014-03-06 [PMID: 24603878] (Bioassay, Human)	Bioassay	Human
Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Bioassay, Human)	Bioassay	Human
Reichwald K, Jorgensen T, Tougaard P, Skov S TL1A induces TCR independent IL-6 and TNF-alpha production and growth of PLZF(+) leukocytes. PLoS ONE, 2014-01-08;9(1):e85793. 2014-01-08 [PMID: 24416448] (Bioassay, Human)	Bioassay	Human
Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V Neutrophil microparticles modulate cytokine production by natural killer cells. Cytokine, 2013-12-16;65(2):126-9. 2013-12-16 [PMID: 24355430] (Bioassay, Human)	Bioassay	Human
Cheng X, He P, Lee T, Yao H, Li R, Shen Y High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014-01-01;184(1):141-7. 2014-01-01 [PMID: 24332014] (Bioassay, Human)	Bioassay	Human
Wang , B, Niu , D, Lam , T H, Xiao , Z, Ren , E C Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell Death Differ, 2013-09-27;21(4):521-32. 2013-09-27 [PMID: 24076587] (Bioassay, Human)	Bioassay	Human
Hawkins R, Larjo A, Tripathi S, Wagner U, Luu Y, Lonnberg T, Raghav S, Lee L, Lund R, Ren B, Lahdesmaki H, Lahesmaa R Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity, 2013-06-20;38(6):1271-84. 2013-06-20 [PMID: 23791644] (Bioassay, Human)	Bioassay	Human
Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol, 2013-05-08;43(7):1727-34. 2013-05-08 [PMID: 23568529] (Bioassay, Mouse)	Bioassay	Mouse
Chen , Qian, Swaminathan , Sanjay, Yang , De, Dai , Lue, Sui , Hongyan, Yang , Jun, Hornung , Ronald L, Wang , Yanmei, Huang , Da Wei, Hu , Xiaojun, Lempicki , Richard, Imamichi , Tomozumi Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE, 2013-03-20;8(3):e59194. 2013-03-20 [PMID: 23527130] (Bioassay, Human)	Bioassay	Human
Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-03-18;190(8):3959-66. 2013-03-18 [PMID: 23509356] (Bioassay, Human)	Bioassay	Human
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156. 2013-02-10 [PMID: 23403044] (Bioassay, Human)	Bioassay	Human
Wilk S, Jenke A, Stehr J, Yang C, Bauer S, Goldner K, Kotsch K, Volk H, Poller W, Schultheiss H, Skurk C, Scheibenbogen C Adiponectin modulates NK-cell function. Eur J Immunol, 2013-03-01;43(4):1024-33. 2013-03-01 [PMID: 23401034] (Bioassay, Human)	Bioassay	Human
Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes. Eur J Immunol, 2013-03-01;43(3):793-804. 2013-03-01 [PMID: 23255246] (Bioassay, Human)	Bioassay	Human
You C, Shi M, Liu Y, Cao M, Luo R, Hermonat P AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC. Oncoimmunology, 2012-09-01;1(6):847-855. 2012-09-01 [PMID: 23162752] (Bioassay, Human)	Bioassay	Human
Flanagan K, Fitzgerald K, Baker J Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07-06;7(7):e40443. 2012-07-06 [PMID: 22792325] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Nielsen N, Odum N, Urso B, Lanier LL, Spee P Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS ONE, 2012-02-22;7(2):e31959. 2012-02-22 [PMID: 22384114] (Bioassay, Human)	Bioassay	Human
Carrier Y, Ma HL, Ramon HE, Napierata L, Small C, O'Toole M, Young DA, Fouser LA, Nickerson-Nutter C, Collins M, Dunussi-Joannopoulos K, Medley QG Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis. J. Invest. Dermatol., 2011-09-01;131(12):2428-37. 2011-09-01 [PMID: 21881584] (Bioassay, Human)	Bioassay	Human
Le Garff-Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre CA, Chapiro E, Davi F, Debre P, Prost JF, Teillaud JL, Merle-Beral H, Vieillard V Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia, 2010-10-26;25(1):101-9. 2010-10-26 [PMID: 20975664] (Bioassay, Human)	Bioassay	Human
Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur. J. Immunol., 2010-09-01;40(9):2450-9. 2010-09-01 [PMID: 20706985] (Bioassay, Human)	Bioassay	Human
Beziat V, Descours B, Parizot C, Debre P, Vieillard V NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE, 2010-08-06;5(8):e11966. 2010-08-06 [PMID: 20700504] (Bioassay, Human)	Bioassay	Human
Ramana Rao PV, Rajasekaran S, Raja A Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. J. Interferon Cytokine Res., 2010-01-01;30(1):33-42. 2010-01-01 [PMID: 20028198] (Bioassay, Human)	Bioassay	Human
Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-12-21;184(3):1642-52. 2009-12-21 [PMID: 20026745] (Bioassay, Human)	Bioassay	Human
Jindra C Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol, 2010-02-01;40(2):321-9. 2010-02-01 [PMID: 19950173] (Bioassay, Human)	Bioassay	Human
Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J. Immunol., 2009-11-01;183(9):5494-501. 2009-11-01 [PMID: 19843935] (Bioassay, Human)	Bioassay	Human
Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 2009-10-01;10(8):702-14. 2009-10-01 [PMID: 19798076] (Bioassay, Human)	Bioassay	Human
De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum., 2009-09-01;60(9):2782-93. 2009-09-01 [PMID: 19714583] (Bioassay, Human)	Bioassay	Human
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-03-02;119(10):1424-32. 2009-03-02 [PMID: 19255340] (Bioassay, Human)	Bioassay	Human
Beziat V, Nguyen S, Lapusan S, Hervier B, Dhedin N, Bories D, Uzunov M, Boudifa A, Trebeden-Negre H, Norol F, Marjanovic Z, Marie JP, Vernant JP, Debre P, Rio B, Vieillard V Fully functional NK cells after unrelated cord blood transplantation. Leukemia, 2009-01-08;23(4):721-8. 2009-01-08 [PMID: 19151772] (Bioassay, Human)	Bioassay	Human
Lee WI, Liang FC, Huang JL, Jaing TH, Wang CH, Lin TY, Huang YC, Huang WL, Jou R, Hsieh MY, Chia JH, Wu TL Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease. J. Clin. Immunol., 2008-12-13;29(3):319-29. 2008-12-13 [PMID: 19089604] (Bioassay, Human)	Bioassay	Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))	ELISA (Standard)
Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C IL-24 modulates IFN-gamma expression in patients with tuberculosis. Immunol. Lett., 2007-12-26;117(1):57-62. 2007-12-26 [PMID: 18199488] (Bioassay, Human)	Bioassay	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (ELISA (Standard))	ELISA (Standard)
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (ELISA (Standard), N/A)	ELISA (Standard)	N/A
de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. Immunology, 2007-05-22;122(2):291-301. 2007-05-22 [PMID: 17521371] (Bioassay, Human)	Bioassay	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Ebert EC, Mehta V Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-08-17;241(1):7-13. 2006-08-17 [PMID: 16914126] (Bioassay, Human)	Bioassay	Human
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-06-16;120(2):220-31. 2006-06-16 [PMID: 16782408] (Bioassay, Human)	Bioassay	Human
Vaknin-Dembinsky A, Balashov K, Weiner HL IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol., 2006-06-15;176(12):7768-74. 2006-06-15 [PMID: 16751425] (ELISA (Specificity Testing))	ELISA (Specificity Testing)
Chapgier A, Wynn RF, Jouanguy E, Filipe-Santos O, Zhang S, Feinberg J, Hawkins K, Casanova JL, Arkwright PD Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J. Immunol., 2006-04-15;176(8):5078-83. 2006-04-15 [PMID: 16585605] (Bioassay, Human)	Bioassay	Human
Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 2006-01-05;107(9):3617-23. 2006-01-05 [PMID: 16397134] (Bioassay, Human)	Bioassay	Human
Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 2005-03-01;52(3):770-8. 2005-03-01 [PMID: 15751070] (Bioassay, Human)	Bioassay	Human
Radstake TR, Roelofs MF, Jenniskens YM, van Riel PL, Barrera P Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum., 2004-12-01;50(12):3856-65. 2004-12-01 [PMID: 15593217] (Bioassay, Human)	Bioassay	Human
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J, Santos OF, Bustamante J, Levy J, Candotti F, Casanova JL A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors. Blood, 2004-06-03;104(7):2095-101. 2004-06-03 [PMID: 15178580] (Bioassay, Human)	Bioassay	Human
Moreaux J, Legouffe E, Jourdan E, Quittet P, Reme T, Lugagne C, Moine P, Rossi JF, Klein B, Tarte K BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood, 2003-12-04;103(8):3148-57. 2003-12-04 [PMID: 15070697] (Bioassay, Human)	Bioassay	Human
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (ELISA (Standard))	ELISA (Standard)
Schmidt KN, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, Wang F, Godowski PJ APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol., 2004-01-01;172(1):138-43. 2004-01-01 [PMID: 14688319] (Bioassay, Human)	Bioassay	Human
Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood, 2003-07-31;102(12):4084-9. 2003-07-31 [PMID: 12893768] (Bioassay, Human)	Bioassay	Human
Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-11-01;76(22):11605-11. 2002-11-01 [PMID: 12388721] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol., 2002-06-01;168(11):5699-708. 2002-06-01 [PMID: 12023369] (Bioassay, Human)	Bioassay	Human
Wolk K, Kunz S, Asadullah K, Sabat R Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol., 2002-06-01;168(11):5397-402. 2002-06-01 [PMID: 12023331] (Bioassay, Human)	Bioassay	Human
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