Recombinant Human IFNA16 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2-4). Structurally, type I IFNs belong to the class of five helical-bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds (5). Mature human IFNA16 shares 60% aa sequence identity with mouse IFNA16. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) (6, 7). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA16 has been shown to be an intermediate inducer of IFN-stimulated genes and anti-viral protection (8). IFNA16 has been shown to be upregulated during chronic HIV infection and might play a role in lipid accumulation and fatty acid deposition in porcine muscle (9, 10).

Array 11156-IF

• IFN-alpha WA/IFNA16 Antibodies
• IFN-alpha WA/IFNA16 Lysate
• IFN-alpha WA/IFNA16 Proteins and Enzymes