Recombinant Human FSH alpha/beta Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Follicle-Stimulating Hormone (FSH) is a 33 kDa heterodimer belonging to the glycoprotein hormone family. It is composed of noncovalently linked glycosylated alpha and beta chains. The alpha subunit is also a component of Luteinizing Hormone (LH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin. The unique beta subunit confers the protein’s specific biological action and is responsible for the interaction with the FSH Receptor (1-3). The approximately 20 kDa alpha subunit of human FSH shares 73% and 72% aa sequence identity with the mouse and rat orthologs, respectively. The approximately 21 kDa human FSH beta subunit shares 85% and 82% aa sequence identity with the mouse and rat orthologs, respectively. FSH is produced and secreted by the anterior pituitary gland. Its secretion is controlled by Gonadotropin-Releasing Hormone from the hypothalamus; however, FSH secretion can also be stimulated by activins and inhibited by inhibins (4-6). FSH works in concert with LH to regulate female reproduction; FSH stimulates follicular growth and LH induces ovulation (7). FSH can also regulate estrogen formation by inducing the aromatase enzyme that converts androgen to estradiol (7, 8). In addition, it has been suggested to have a role in postmenopausal bone loss and in the neovascularization surrounding malignant tumors (9-11). In males, FSH is critical for sperm production (12). Mutations in the human FSH and FSHR genes are associated with reduced reproductive functioning in females (2, 11). Additionally, increased production of autoantibodies directed against FSH beta has been suggested to contribute to certain types of female infertility (2). Assisted reproductive technology commonly uses recombinant FSH to induce follicle growth (7).

We have publications tested in 3 confirmed species: Human, Mouse, Chicken.

We have publications tested in 3 applications: Bioassay, Cell Culture, Stimulation.

Showing Publications 1 - 10 of 10.

Publications using 5925-FS	Applications	Species
Y Zhang, Q Chen, Y Guo, L Kang, Y Sun, Y Jiang Phosphoproteomic analysis on ovarian follicles reveals the involvement of LSD1 phosphorylation in Chicken follicle selection BMC Genomics, 2023-03-13;24(1):109. 2023-03-13 [PMID: 36915048] (Bioassay, Chicken)	Bioassay	Chicken
S Qiao, S Alasmi, A Wyatt, P Wartenberg, H Wang, M Candlish, D Das, M Aoki, R Grünewald, Z Zhou, Q Tian, Q Yu, V Götz, A Belkacemi, A Raza, F Ectors, K Kattler, G Gasparoni, J Walter, P Lipp, P Mollard, DJ Bernard, E Karatayli, SC Karatayli, F Lammert, U Boehm Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice Nature Communications, 2023-02-25;14(1):1098. 2023-02-25 [PMID: 36841874] (Bioassay, Mouse)	Bioassay	Mouse
FL Zhang, YQ Feng, JY Wang, KX Zhu, L Wang, JM Yan, XX Li, JJ Wang, W Ge, M De Felici, W Shen Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch Cell Death & Disease, 2023-02-17;14(2):134. 2023-02-17 [PMID: 36797258] (Bioassay, Mouse)	Bioassay	Mouse
X Yu, F Meng, J Huang, W Li, J Zhang, S Yin, L Zhang, S Wang 1-Nitropyrene exposure induces mitochondria dysfunction and impairs oocyte maturation in mice Ecotoxicology and environmental safety, 2022-07-28;242(0):113921. 2022-07-28 [PMID: 35908531] (Stimulation, Mouse)	Stimulation	Mouse
Q Chen, Y Wang, Z Liu, X Guo, Y Sun, L Kang, Y Jiang Transcriptomic and proteomic analyses of ovarian follicles reveal the role of VLDLR in chicken follicle selection BMC Genomics, 2020-07-16;21(1):486. 2020-07-16 [PMID: 32677893] (Cell Culture, Human)	Cell Culture	Human
J Li, W Luo, T Huang, Y Gong Growth differentiation factor 9 promotes follicle-stimulating hormone-induced progesterone production in chicken follicular granulosa cells Gen. Comp. Endocrinol., 2019-03-06;0(0):. 2019-03-06 [PMID: 30851298] (Bioassay, Chicken)	Bioassay	Chicken
W Marlicz, A Poniewiers, S Rzeszotek, R Bartoszews, K Skonieczna, T Starzy?ska, MZ Ratajczak A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer PLoS ONE, 2018-03-01;13(3):e0189337. 2018-03-01 [PMID: 29494614] (Bioassay, Human)	Bioassay	Human
S Mizumachi, T Aritomi, K Sasaki, K Matsubara, Y Hirao Macromolecular crowded conditions strengthen contacts between mouse oocytes and companion granulosa cells during in vitro growth J. Reprod. Dev., 2018-02-16;0(0):. 2018-02-16 [PMID: 29459533] (Cell Culture, Mouse)	Cell Culture	Mouse
D Jung, J Xiong, M Ye, X Qin, L Li, S Cheng, M Luo, J Peng, J Dong, F Tang, W Shen, MM Matzuk, K Kee In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells Nat Commun, 2017-06-12;8(0):15680. 2017-06-12 [PMID: 28604658] (Bioassay, Human)	Bioassay	Human
T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells Sci Rep, 2017-01-23;7(0):41304. 2017-01-23 [PMID: 28112253] (Bioassay, Mouse)	Bioassay	Mouse

Array 5925-FS

• FSH alpha/beta ELISA Kits
• FSH alpha/beta Proteins and Enzymes