Recombinant Human CRELD1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cysteine-rich with EGF-like domain protein 1 (CRELD1) is an approximately 50 kDa transmembrane glycoprotein that contains a 333 amino acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa (1). Alternative splicing of human CRELD1 generates an additional isoform with a substitution that encompasses the transmembrane segments and the C‑terminal ECD (1). CRELD1 is widely expressed during development and in the adult (1). It interacts with Reticulon 3/RTN3 and inhibits the pro‑apoptotic activity of RTN3 (2). CRELD1 also associates with Adrenergic alpha ₁ receptors in the prostate and limits their expression (3). Missense mutations of human CRELD1 are associated with susceptibility to atrioventricular septal defects in the heart (4). R&D Systems in‑house testing indicates that CRELD1 mediates the adhesion of ATDC-5 cells.

Array 3128-CR

• CRELD1 Antibodies
• CRELD1 ELISA Kits
• CRELD1 Lysates
• CRELD1 Protein
• CRELD1 Proteins and Enzymes