Recombinant Human CD163 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD163, also known as M130, is a 130-160 kDa type I transmembrane glycoprotein that belongs to group B of the cysteine-rich scavenger receptor family (1-3). It is essential for clearance of hemoglobin-haptoglobin (Hb-Hp) complexes in the liver, spleen and circulation (4). The human CD163 contains a 41 amino acid (aa) signal sequence, a 1009 aa extracellular domain (ECD) with 9 scavenger receptor cysteine-rich (SRCR) domains, a 21 aa transmembrane segment, and an 85 aa cytoplasmic region. The third SRCR domain is crucial for calcium-dependent binding of hemoglobin/haptoglobin complexes (2). While all are expressed, isoform 3 is the most abundant, being generally expressed on the cell surface and most active in endocytosis (5). Expression of CD163 is constitutive, and induced by glucocorticoids, IL­10, IL­6 or endotoxin on circulating monocytes, tissue macrophages, and at low levels on monocyte­derived dendritic cells (1, 6-7). In addition to clearing Hb­Hp complexes, CD163 is also a scavenger receptor for free Hb (if Hp is depleted) and TWEAK (TNF­like weak inducer of apoptosis) and can function as an erythroblast adhesion receptor (4, 8­, 10). The macrophage scavenger receptor CD163, which is upregulated in a number of inflammatory and malignant diseases, is a promising target on macrophages in anti-inflammatory and anti-cancer therapy in avoiding off-target effects on treatment of these diseases (11).

Array 11228-CD

• CD163 Antibodies
• CD163 ELISA Kits
• CD163 Lysate
• CD163 Proteins
• CD163 ELISAs
• CD163 Proteins and Enzymes