Recombinant Human Activin RIA/ALK-2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine/threonine kinase receptor family (1-3). Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins (1, 2). Activin RIA functions in a wide variety of growth and differentiation processes including gastrulation, skeletal system development, and cardiac morphogenesis
(1, 4-7). Mature human Activin RIA consists of a 103 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 363 aa cytoplasmic region that includes a Gly/Ser-rich GS box and the kinase domain (8, 9). Within the ECD, human Activin RIA shares 99% and 94% aa sequence identity with mouse and rat Activin RIA, respectively. It shares 20%-26% aa sequence identity with other human type I receptors Activin RIB, BMPR-IA, BMPR-IB, and TGF-beta RI. BMP signaling through Activin RIA is enhanced by the direct interaction between Activin RIA and RGM-B/DRAGON, a BMP coreceptor that also associates with other type I and type II receptors (10). Activin RIA can additionally phosphorylate the coreceptor Endoglin and is required for the inhibitory effect of Endoglin on prostate cancer cell motility (11).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (detection), Receptor Binding Assay, Surface Plasmon Resonance.

Showing Publications 1 - 4 of 4.

Publications using 637-AR	Applications	Species
B Huang, Y Yuan, T Li, S Ding, W Zhang, Y Gu, C Liu Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface Sci Rep, 2016-04-14;6(0):24323. 2016-04-14 [PMID: 27075233] (Bioassay, Mouse)	Bioassay	Mouse
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-07-07;286(34):30034-46. 2011-07-07 [PMID: 21737454] (Surface Plasmon Resonance, Mouse)	Surface Plasmon Resonance	Mouse
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-07-02;381(4):1025-39. 2008-07-02 [PMID: 18621057] (ELISA (detection), Surface Plasmon Resonance, Human)	ELISA (detection), Surface Plasmon Resonance	Human
Reversade B, De Robertis EM Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell, 2005-12-16;123(6):1147-60. 2005-12-16 [PMID: 16360041] (Receptor Binding Assay, Human)	Receptor Binding Assay	Human

Array 637-AR

• Activin RIA/ALK-2/Activin Receptor Type 1 Antibodies
• Activin RIA/ALK-2/Activin Receptor Type 1 ELISA Kits
• Activin RIA/ALK-2/Activin Receptor Type 1 Lysates
• Activin RIA/ALK-2/Activin Receptor Type 1 Proteins
• Activin RIA/ALK-2/Activin Receptor Type 1 Proteins and Enzymes