Recombinant Cynomolgus Monkey uPAR His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Urokinase plasminogen activator receptor (uPAR), also known as CD87, is a cysteine-rich cell surface glycoprotein belonging to the Ly6/uPAR (LU) superfamily and is involved in the activation of plasminogen to plasmin (1). Mature uPAR consists of an extracellular domain (ECD) with 3 LU domains (D1, D2, and D3) similar to Ly‑6 antigens and snake venom alpha -neurotoxins and a C-terminal glycosyl-phosphatidylinositol (GPI) anchor linked to the last residue of the third LU domain (1-3). The ECD of mature cynomolgus uPAR shares 95% amino acid sequence identity with human uPAR. Posttranslational modification generates several soluble uPAR fragments including uPAR, uPAR DIIDIII, and uPAR DI in human (1-3). The urokinase-type Plasminogen Activator (uPA) is one of two activators that converts the extracellular zymogen plasminogen to plasmin. The binding of uPAR with uPA initiates a proteolytic cascade resulting in the degradation of extracellular matrix components and stimulates tissue remodeling (4). The uPAR/uPA interaction also initiates signal transduction responses resulting in activation of protein tyrosine kinases, gene expression, cell adhesion, and chemotaxis (4). uPAR can interact with integrins to suppress normal integrin adhesive function and promote adhesion to vitronectin through a high affinity vitronectin binding site (5, 6). uPAR expression is limited in normal human tissue but is highly expressed by diverse cancer cells and by non-malignant cells that infiltrate cancers and uPAR expression is associated with poor prognosis and increased risk of metastasis (7). uPAR is considered as a biomarker in many inflammatory diseases including cancer, cardiovascular diseases, chronic kidney diseases and diabetes (6).

Array 10949-UK

• uPAR Antibodies
• uPAR Antibody Pair
• uPAR Lysate
• uPAR Proteins
• uPAR Proteins and Enzymes
• uPAR ELISAs