Rad51 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using H00005888-B01P	Applications	Species
Youngho K, Heike R, Weixing Z et al. DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation. Nat Commun. 2023-01-26 [PMID: 36702902]
Q Zhao, K Liu, L Zhang, Z Li, L Wang, J Cao, Y Xu, A Zheng, Q Chen, T Zhao BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination Cell Death & Disease, 2022-11-19;13(11):976. 2022-11-19 [PMID: 36402748]
Chaoyou X, Sameer S, Nozomi T et al. Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing. Nat Commun. 2022-04-26 [PMID: 35473934]
Duncan S, Nicola F, May M et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol. 2021-03-03 [PMID: 33662256]
Yoshimura Y Increased error-free DNA repair gene expression through reprogramming in human iPS cells Regenerative Therapy 2019-06-28 [PMID: 31304203] (WB, Human)	WB	Human
Shi L, Sun J, Kinomura A et al. Matrin3 promotes homologous recombinational repair by regulation of RAD51. J Biochem. 2019-05-23 [PMID: 31119278]
Qi F, Meng Q, Hayashi I, and Kobayashi J Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses. J Radiat Res. 2019-05-01 [PMID: 30839063]
He DJ, Wang L, Zhang ZB et al. Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. Zool Res 2018-06-15 [PMID: 29955025]
Cagnetta A, Soncini D, Orecchioni S et al. Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents. Haematologica. 2017-10-12 [PMID: 29025907] (Human)		Human
Tan SLW, Chadha S, Liu Y et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell 2017-06-01 [PMID: 28575672]
Cea M, Cagnetta A, Adamia S et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood Journal. 2016-03-03 [PMID: 26675349] (IF/IHC, Human)	IF/IHC	Human
Lesterlin C, Ball G, Schermelleh L, Sherratt DJ. RecA bundles mediate homology pairing between distant sisters during DNA break repair. Nature. 2013-12-22 [PMID: 24362571]
Jeyasekharan AD, Liu Y, Hattori H et al. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol. 2013-09-08 [PMID: 24013206]
Show All 13 Publications. Collapse Publications.

Array H00005888-B01P

• Rad51 Antibodies
• Rad51 Lysates
• Rad51 Protein