Rad51 Antibody (13E4)

Rad51, a 37 kDa protein, is the human homologue of E. coli RecA protein and a member of the RAD52 epistasis group in S. cerevisiae. In recent studies it has been reported that BRCA1 interacts with Rad51 and disease-causing mutations have been found in the BRCA1 region necessary for BRCA1/Rad51 interaction, implying that this interaction is important for tumor suppression. BRCA2 and Rad51 have also been shown to interact by direct binding of the BRC repeats located within exon 11 of BRCA2. When these repeats are deleted, the interaction is lost and cells become hypersensitive to the DNA damage caused by methyl methanesulfonate (MMS).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, PLA, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-499	Applications	Species
Argenton F, Martello G, Tiso N et al. STAT3 and HIF1alpha cooperatively mediate the transcriptional and physiological responses to hypoxia Research Square 2023-04-04 (PLA, Mouse)	PLA	Mouse
Dinarello A, Betto RM, Diamante L et al. STAT3 and HIF1? cooperatively mediate the transcriptional and physiological responses to hypoxia Cell Death Discovery 2023-07-05 [PMID: 37407568]
Vugic D, Dumoulin I, Martin C et al. Replication Gap Suppression Depends on the Double-Strand DNA Binding Activity of BRCA2 SSRN Electronic Journal 2022-04-15 [PMID: 36707518]
Chen B, Xu F, Gao Y et al. DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity Oncogene 2022-02-12 [PMID: 35152263] (ICC/IF, Human)	ICC/IF	Human
van Kuijk K, Demandt JAF, Perales-PatOn J et al. DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic effects of myeloid PHD knockdown Cardiovascular research 2021-04-26 [PMID: 33913468]
Torretta S, Scagliola A, Ricci L et al. D-mannose suppresses macrophage IL-1 beta production Nature communications 2020-12-11 [PMID: 33311467]
Dukel M, Streitfeld WS, Tang TC et al. The Breast Cancer Tumor Suppressor TRIM29 is Expressed via ATM-Dependent Signaling in Response to Hypoxia. J. Biol. Chem. 2016-08-17 [PMID: 27535224] (WB)	WB
Revheim ME, Kristian A, Malinen E et al. Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H Acta Oncol 2013-05-01 [PMID: 23480638] (IF/IHC, Human)	IF/IHC	Human
Gultice AD, Kulkarni-Datar K, Brown TL. Hypoxia-Inducible Factor 1alpha (HIF1A) Mediates Distinct Steps of Rat Trophoblast Differentiation in Gradient Oxygen. Biol Reprod;80(1):184-193. 2009-01-01 [PMID: 18815358]

Array NB100-499

• Rad51 Antibodies
• Rad51 ELISA Kits
• Rad51 Lysates
• Rad51 Protein