PYK2/FAK2 Antibody (1F9)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using H00002185-M01	Applications	Species
Sarin N, Engel F, Rothweiler F et al. Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. Int J Mol Sci. 2018-03-07 [PMID: 29518977]

Array H00002185-M01

• PYK2/FAK2 Antibodies
• PYK2/FAK2 Lysates
• PYK2/FAK2 Proteins
• PYK2/FAK2 Proteins and Enzyme