PrPSc Antibody (1.5D7) Summary
Immunogen |
BoPrP153-165 (GSDYEDRYYRENM) |
Specificity |
The monoclonal antibody 1.5D7 recognizes the disease associated isoform of the prion protein termed PrPSc. |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
PRNP |
Purity |
Protein G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunoassay
- Immunohistochemistry-Frozen
- Immunohistochemistry-Paraffin
- Western Blot
|
Application Notes |
The monoclonal antibody can be used for the specific identification and characterization of PrPSc in tissue sections by immunohistochemistry and PET-blot. For immunohistochemistry, and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. |
Packaging, Storage & Formulations
Storage |
Store at 4C. |
Buffer |
0.2 um filtered solution in PBS, 0.1% BSA |
Preservative |
0.02% Sodium Azide |
Concentration |
0.1 mg/ml |
Purity |
Protein G purified |
Alternate Names for PrPSc Antibody (1.5D7)
Background
Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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