Species: Hu, Ha
Applications: WB, ELISA, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Bv
Applications: WB, ELISA, IP
Host: Rabbit Monoclonal
Species: Hu, Mu, Bv, Ha, Sh
Applications: WB, ELISA, IHC
Host: Mouse Monoclonal
Description
Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).
Bioinformatics
| Product By Gene ID |
5621 |
| Alternate Names |
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