Prohibitin 2 Antibody

REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases. Alternate names for REA include B-cell receptor-associated protein BAP37, D-prohibitin, PHB2, BAP, p22, BCAP37, PNAS-141, and MGC117268.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using NB100-1807	Applications	Species
Liu D, Lin Y, Kang T et al. Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. PLoS One 2012-01-01 [PMID: 22479600]
Strub GM, Paillard M, Liang J et al. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J 2011-02-01 [PMID: 20959514]
He B, Feng Q, Mukherjee A et al. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol 2008-02-01 [PMID: 17932104]

Array NB100-1807

• Prohibitin 2 Antibodies
• Prohibitin 2 Lysates
• Prohibitin 2 Proteins