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PPP1R3B Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: PPP1R3B Antibody [NBP1-82243] - Staining in human liver and lymph node tissues . Corresponding PPP1R3B RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: PPP1R3B Antibody [NBP1-82243] - Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
Immunohistochemistry-Paraffin: PPP1R3B Antibody [NBP1-82243] - Staining of human lymph node shows only very weak positivity in lymphoid cells.
Immunohistochemistry-Paraffin: PPP1R3B Antibody [NBP1-82243] - Staining of human rectum shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: PPP1R3B Antibody [NBP1-82243] - Staining of human skeletal muscle shows moderate to strong cytoplasmic positivity in striated muscle fibers.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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PPP1R3B Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: DRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRIIRAELKSTQGMTKPHSGPDLGISFDQFGSPRCSYGLF
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PPP1R3B
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
PPP1R3B Protein (NBP1-82243PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (83%), Rat (88%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for PPP1R3B Antibody

  • FLJ14005
  • FLJ34675
  • GL
  • Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
  • PPP1R4PP1 subunit R4
  • protein phosphatase 1 regulatory subunit 3B
  • Protein phosphatase 1 regulatory subunit 4
  • Protein phosphatase 1 subunit GL
  • protein phosphatase 1, regulatory (inhibitor) subunit 3B

Background

PPP1R3B, the protein phosphatase-1 (PP1) catalytic subunit (PPP1CA; MIM 176875) is regulated by targeting subunits, such as PP1R3B. PP1R3B suppresses the rate at which PP1 dephosphorylates (i.e., inactivates) glycogen phosphorylase (see PYGL; MIM 232700) and enhances the rate at which it activates glycogen synthase (see GYS2; MIM 138571) (Doherty et al., 1995 [PubMed 7498521]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PPP1R3B