PKC iota Antibody

PKC iota encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-84959	Applications	Species
Li F, Negi V, Yang P et al. TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism Nucleic acids research 2022-12-09 [PMID: 36484096] (WB, Human)	WB	Human
Weatherly SM, Collin GB, Charette JR et al. Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model PLOS Genetics 2022-06-08 [PMID: 35675330] (WB)	WB
Guo G, Stirparo GG, Strawbridge SE et al. Human naive epiblast cells possess unrestricted lineage potential Cell stem cell 2021-04-03 [PMID: 33831366]

Array NBP1-84959

• PKC iota Antibodies
• PKC iota Lysate
• PKC iota Proteins