PI 3-Kinase p55 gamma Antibody (668619) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

p55 gamma (Protein of 55 kDa, gamma subunit; also PI3-kinase regulatory subunit gamma and p55PIK) is a 55-57 kDa member of the PI3K p85 family of regulatory subunits. It is widely expressed, and serves as a recruitment subunit for the p110 catalytic subunit of PI3 kinase. p55 gamma /p55PIK should not be confused with the 55 kDa alpha splice variant of the p85a gene (75% amino acid [aa] identity). Human p55 gamma is 461 aa in length. It contains a unique 34 aa N-terminus that binds Rb and prevents cycle progression, followed by a Pro-rich region (aa 35-44) and two SH2 domains that bind the p110 catalytic subunit (aa 65-160 and 358-452). Based on mouse, it is likely that alternate start sites at Met8 and Met32 generate 54 and 50 kDa protein products, respectively. There is also a potential for a start site 18 aa upstream of the standard start site, as well as a splice form that shows a deletion of aa 256-314 that may be accompanied by an additional deletion of aa 36-71. Over aa 251-378, human p55 gamma shares 94% aa identity with mouse p55 gamma .

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB6638	Applications	Species
Kyung W. Song, Kyle A. Edgar, Emily J. Hanan, Marc Hafner, Jason Oeh, Mark Merchant et al. RTK-Dependent Inducible Degradation of Mutant PI3K alpha Drives GDC-0077 (Inavolisib) Efficacy Cancer Discovery 2022-01-01 [PMID: 34544753]
Tourette , Cendrine, Li , Biao, Bell , Russell, O'Hare , Shannon, Kaltenbach , Linda S, Mooney , Sean D, Hughes , Robert E A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. J Biol Chem, 2014-01-09;289(10):6709-26. 2014-01-09 [PMID: 24407293] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB6638

• PI 3-Kinase p55 gamma Antibodies
• PI 3-Kinase p55 gamma Lysates
• PI 3-Kinase p55 gamma Proteins