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Peroxiredoxin 6 Antibody (1A9W5)

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Western Blot: Peroxiredoxin 6 Antibody (1A9W5) [NBP3-16369] - Western blot analysis of extracts of various cell lines, using Peroxiredoxin 6 Rabbit mAb (NBP3-16369) at 1:1000 dilution. Secondary antibody: HRP Goat ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
1A9W5
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Peroxiredoxin 6 Antibody (1A9W5) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 125-224 of human Peroxiredoxin 6 (NP_004896.1). KGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
PRDX6
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500 - 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Peroxiredoxin 6 Antibody (1A9W5)

  • 1-Cys
  • 24 kDa protein
  • Acidic calcium-independent phospholipase A2
  • aiPLA2
  • aiPLA21-Cys PRX
  • Antioxidant protein 2
  • AOP2
  • AOP2Non-selenium glutathione peroxidase
  • EC 1.11.1.15
  • EC 1.11.1.7
  • EC 3.1.1.-
  • KIAA0106Red blood cells page spot 12
  • Liver 2D page spot 40
  • MGC46173
  • NSGPx
  • NSGPx1-Cys peroxiredoxin
  • p29
  • Peroxiredoxin 6
  • peroxiredoxin-6
  • PRDX6
  • PRX

Background

FUNCTION: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. SUBUNIT: Homotetramer. May interact with HTR2A. SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Note=Also found in lung secretory organelles. MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin . MISCELLANEOUS: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PRDX6