Peripherin Antibody

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Peripherin (PRPH) is a 57kD type III neuronal intermediate filament (NIF) protein which is predominantly expressed in neurons of PNS and in certain CNS neurons specifically from brain stem/spinal cord which generally project toward peripheral structures. Inside developing neurons, PRPH is expressed abundantly in the growth cones and is required for axonal outgrowth as well as maintenance or regeneration. In mature neurons, together with other NIFs, PRPH constitutes a shape-maintaining IF network. Besides its crucial role in development of nervous system, PRPH can also be highly relevant to pathogenesis of neurodegenerative disorder. PRPH expression is induced in CNS neurons (wherein it is not expressed normally) upon brain injury, and factors such as LIF, IL-6 etc and PRPH molecules form aggregates in neurons. Synaptic plasticity is markedly altered in PRPH transgenic mice (Per mice) and up-regulation of PRPH expression is implicated in some pathophysiological conditions, such as cerebral ischemia and seizure, and some cognitive disorders. In ALS patients, PRPH together with neuronal IFs are detected in the majority of abnormal IF inclusion bodies in mature or aging motor neurons.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, IHC-Fr.

Showing Publications 1 - 7 of 7.

Publications using NBP1-05423	Applications	Species
de la Pe�a JB, Chase R, Kunder N et al. Inhibition of nonsense-mediated decay induces nociceptive sensitization through activation of the integrated stress response The Journal of neuroscience : the official journal of the Society for Neuroscience 2023-03-09 [PMID: 36894318]
de la Pena JB, Kunder N, Lou TF, Chase R RNA CONTROL IN SENSORY NEURONS: A FUNCTIONAL GENOMICS APPROACH Thesis 2023-01-01 (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Smith PR, Meyer A, Loerch S, Campbell ZT Protocol for the isolation and culture of mouse dorsal root ganglion neurons for imaging applications STAR protocols 2023-11-14 [PMID: 37967016]
Lillyman D, Lee F, Barnett E et al. Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats JOR SPINE 2022-07-14 [PMID: 36203864] (IHC-Fr, Rat) Details: Sprague Dawley rats L5-L6 motion segments, antibody used at 1:1000	IHC-Fr	Rat
Bryan de la PeNa J, Kunder N, Lou TF Et al. A Role for Translational Regulation by S6 Kinase and a Downstream Target in Inflammatory Pain British journal of pharmacology 2021-08-06 [PMID: 34355805]
de la PeNa JB, Barragan-Iglesias P, Lou TF Et al. Intercellular Arc Signaling Regulates Vasodilation The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-07-29 [PMID: 34326146]
Lillyman D Development of a Decellularized Hydrogel Composite and its Application in a Novel Model of Disc-associated Low Back Pain in Female Sprague Dawley Rats Thesis 2022-01-01 (IHC-Fr, Rat) Details: Dilution used for IHC 1:1000	IHC-Fr	Rat

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Thomas Finger	IHC-Fr	Human	09/17/2018	View Summary Application Immunohistochemistry-Frozen Sample Tested larynx Species Human Lot 71212 Comments Comments Fixation 4% buffered paraformaldehyde.
Enlarge	4 reviewed by: Thomas Finger	IHC-Fr	Mouse	09/17/2018	View Summary Application Immunohistochemistry-Frozen Sample Tested Mouse brain Species Mouse Lot 71212 Comments Comments Tested on both human and mouse tissues. Works well for staining of small diameter nerve fibers in peripheral tissues. Less effective in staining central terminals of sensory axons (mouse) but still effective (see image).

Array NBP1-05423

• Peripherin Antibodies
• Peripherin Lysate
• Peripherin Proteins