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PARC Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77222AF350
Alexa Fluor 405
NBP1-77222AF405
Alexa Fluor 488
NBP1-77222AF488
Alexa Fluor 532
NBP1-77222AF532
Alexa Fluor 594
NBP1-77222AF594
Alexa Fluor 647
NBP1-77222AF647
Alexa Fluor 700
NBP1-77222AF700
Alexa Fluor 750
NBP1-77222AF750
Biotin
NBP1-77222B
CoraFluor 1
NBP1-77222CL1
DyLight 350
NBP1-77222UV
DyLight 488
NBP1-77222G
DyLight 550
NBP1-77222R
DyLight 594
NBP1-77222DL594
DyLight 650
NBP1-77222C
DyLight 680
NBP1-77222FR
DyLight 755
NBP1-77222IR
FITC
NBP1-77222F
HRP
NBP1-77222H
Janelia Fluor 525
NBP1-77222JF525
Janelia Fluor 549
NBP1-77222JF549
Janelia Fluor 585
NBP1-77222JF585
Janelia Fluor 635
NBP1-77222JF635
Janelia Fluor 646
NBP1-77222JF646
Janelia Fluor 669
NBP1-77222JF669
PerCP
NBP1-77222PCP
Unconjugated
NBP1-77222
mFluor Violet 450 SE
NBP1-77222MFV450
mFluor Violet 500 SE
NBP1-77222MFV500
mFluor Violet 610 SE
NBP1-77222MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77222
BSA Free
NBP1-77222
BSA Free
NBP1-77222-0.025mg
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PARC Antibody [DyLight 405] Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PARC. The immunogen is located within the last 50 amino acids of PARC. Amino Acid Squence: DNDSFSYDESENLDQET
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CUL9
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PARC Antibody [DyLight 405]

  • CUL-9
  • cullin 9
  • cullin-9
  • DKFZp686G1042
  • H7AP1DKFZp686P2024
  • p53-associated parkin-like cytoplasmic protein
  • PARCKIAA0708
  • parkin-like cytoplasmic p53 binding protein
  • RP3-330M21.2
  • UbcH7-associated protein 1

Background

PARC is a cytoplasmic anchor protein in p53 associated protein complexes. PARC directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines; RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CUL9