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Pappalysin-1/PAPP-A Antibody (10E1cc) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IP
Clone
10E1cc
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB120-8346AF350
Alexa Fluor 405
NB120-8346AF405
Alexa Fluor 488
NB120-8346AF488
Alexa Fluor 532
NB120-8346AF532
Alexa Fluor 594
NB120-8346AF594
Alexa Fluor 647
NB120-8346AF647
Alexa Fluor 700
NB120-8346AF700
Alexa Fluor 750
NB120-8346AF750
Biotin
NB120-8346B
DyLight 350
NB120-8346UV
DyLight 405
NB120-8346V
DyLight 488
NB120-8346G
DyLight 550
NB120-8346R
DyLight 594
NB120-8346DL594
DyLight 650
NB120-8346C
DyLight 680
NB120-8346FR
DyLight 755
NB120-8346IR
FITC
NB120-8346F
HRP
NB120-8346H
Janelia Fluor 525
NB120-8346JF525
Janelia Fluor 646
NB120-8346JF646
Janelia Fluor 669
NB120-8346JF669
Unconjugated
NB120-8346
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Pappalysin-1/PAPP-A Antibody (10E1cc) [Janelia Fluor® 549] Summary

Immunogen
Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with purified human PAPP-A/proMBP (heterotetrameric PAPP-A, htPAPP-A) complex.
Specificity
Human PAPP-A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP-A subunits and proMBP subunits).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
PAPPA
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Sandwich ELISA
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Pappalysin-1/PAPP-A Antibody (10E1cc) [Janelia Fluor® 549]

  • ASBABP2
  • DIPLA1
  • EC 3.4.24.79
  • IGFBP-4ase
  • IGFBP-4aseaspecific BCL2 ARE-binding protein 2
  • IGF-dependent IGFBP-4 protease
  • insulin-like growth factor-dependent IGF binding protein-4 protease
  • Insulin-like growth factor-dependent IGF-binding protein 4 protease
  • PAPA
  • PAPPA
  • PAPPA1
  • PAPP-A1
  • PAPP-Adifferentially placenta 1 expressed protein
  • Pappalysin1
  • Pappalysin-1
  • pregnacy-associated plasma protein A
  • Pregnancy-associated plasma protein A
  • pregnancy-associated plasma protein A, pappalysin 1

Background

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Pappalysin-1/PAPP-A An ...
NB120-8346JF549
Pappalysin-1/PAPP-A Antibody (10E1cc) [Janelia Fluor® 549]
Species: Hu
Applications: WB, ELISA, IP

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FAQs for Pappalysin-1/PAPP-A Antibody (NB120-8346JF549). (Showing 1 - 1 of 1 FAQ).

  1. I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).
    • Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.

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Bioinformatics

Gene Symbol PAPPA