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P2X7/P2RX7 Antibody (Hano43) [PE/Cy7]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, ICC/IF
Clone
Hano43
Clonality
Monoclonal
Host
Rat
Conjugate
PE/Cy7

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Datasheet
Reviews & Publications
Protocols & FAQs
Support & Research

P2X7/P2RX7 Antibody (Hano43) [PE/Cy7] Summary

Immunogen
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells
Specificity
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
P2RX7
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Reactivity Notes

Reacts with Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for P2X7/P2RX7 Antibody (Hano43) [PE/Cy7]

  • ATP receptor
  • MGC20089
  • P2RX7
  • P2X purinoceptor 7
  • P2X7
  • P2X7P2X7 receptor
  • P2X7R
  • P2Z receptor
  • purinergic receptor P2X, ligand-gated ion channel, 7
  • purinergic receptor P2X7 variant A
  • Purinergic receptor

Background

FUNCTION: Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.; Subcellular location: Membrane; Multi-pass membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol P2RX7