Pannexin-1 Antibody (720505)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Pannexin-1 (PANX1) is an approximately 45 kDa member of the Pannexin family of four-transmembrane channel proteins with a conserved pattern of cysteines. It is expressed on epithelial cells, neuronal and glial cells, cardiac myocytes, T cells, and erythrocytes. Pannexin-1 forms large pore hexameric channels or heteromeric channels with Pannexin-2 and enables the efflux of ATP and UTP. Its conductance is increased in response to hypoxia, isotonic stress, NMDA R activation, and Caspase-3 and -7 activation during apopotosis. Extracellular release of ATP through Pannexin-1 activates P2X7 receptors which in turn induces the closure of Pannexin-1 channels. Pannexin-1 cooperates with P2X7 for inflammasome activation, Caspase-1 activation, and the release of mature IL-1 beta and also regulates T cell activation at the immunological synapse. Within aa 298-376 (in the C-terminal cytoplasmic domain), human Pannexin-1 shares 96% and 98% aa sequence identity with mouse and rat Pannexin-1, respectively. Alternate splicing generates an additional isoform that lacks the C-terminal four amino acids in the cytoplasmic tail.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using MAB7097	Applications	Species
S Senthivina, V Serbulea, CM Upchurch, R Polanowska, SK Mendu, S Sahu, P Jayaguru, KW Aylor, MD Chordia, L Steinberg, N Oberholzer, S Uchiyama, N Inada, UM Lorenz, TE Harris, SR Keller, AK Meher, A Kadl, BN Desai, BK Kundu, N Leitinger Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels Mol Metab, 2020-11-25;0(0):101130. 2020-11-25 [PMID: 33248294] (Western Blot, Mouse)	Western Blot	Mouse
C Flores-Muñ, B Gómez, E Mery, P Mujica, I Gajardo, C Córdova, D Lopez-Espí, C Durán-Anio, C Hetz, P Muñoz, AM Gonzalez-J, ÁO Ardiles Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease Front Cell Neurosci, 2020-03-19;14(0):46. 2020-03-19 [PMID: 32265655] (IHC-P, Mouse)	IHC-P	Mouse
M Adamiak, K Bujko, M Cymer, M Plonka, T Glaser, M Kucia, J Ratajczak, H Ulrich, A Abdel-Lati, MZ Ratajczak Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells Leukemia, 2018-03-30;0(0):. 2018-03-30 [PMID: 29725032] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
N Hainz, A Beckmann, M Schubert, A Haase, U Martin, T Tschernig, C Meier Human stem cells express pannexins BMC Res Notes, 2018-01-22;11(1):54. 2018-01-22 [PMID: 29357945] (Western Blot, Human)	Western Blot	Human

Array MAB7097

• Pannexin-1 Antibodies
• Pannexin-1 Lysate
• Pannexin-1 Proteins