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Osteoprotegerin/TNFRSF11B Antibody (69127) [Unconjugated]

 (8 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA(Cap)
Clone
69127
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB8051-SP
Carrier Free
MAB8051-500
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Osteoprotegerin/TNFRSF11B Antibody (69127) [Unconjugated] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Osteoprotegerin/TNFRSF11B
Glu22-Leu401
Accession # O00300
Specificity
Detects human Osteoprotegerin/TNFRSF11B in ELISAs. It has been reported (1), and R&D Systems testing has confirmed, that this antibody shows strong cross-reactivity with an unrelated protein, human Carbonic Anhydrase II. In Western blots, this antibody does not cross‑react with recombinant human (rh) 4‑1BB, rhCD27, rhCD30, recombinant mouse (rm) CD30, rmCD40, rhDR3, rhDR6, rhFas, rmFas, rhGITR, rmGITR, rhHVEM, rhLT beta R, rhNGF R, rmOPG, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF11B
Purity Statement
Protein A or G purified from ascites
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Applications/Dilutions

Dilutions
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Detection: Human Osteoprotegerin/TNFRSF11B Biotinylated Antibody (Catalog number BAF805)
Standard: Recombinant Human Osteoprotegerin/TNFRSF11B (Catalog number 185-OS)
Publications
Read Publications using
MAB8051 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Osteoprotegerin/TNFRSF11B Antibody (69127) [Unconjugated]

  • OCIF
  • OCIFMGC29565
  • OPG
  • OPGtumor necrosis factor receptor superfamily member 11B
  • Osteoclastogenesis inhibitory factor
  • Osteoprotegerin
  • TNFRSF11B
  • TR1
  • tumor necrosis factor receptor superfamily, member 11b

Background

Osteoprotegerin is a member of the TNF receptor superfamily expressed by many cell types. It exists in soluble monomeric and dimeric forms as a decoy receptor for its ligands, TRANCE and TRAIL. Osteoprotegerin functions as an antagonist to RANKL-induced osteoclastogenesis and bone resorption.

  1. Waterman, E.A. et al. (2007) Intl. J. Cancer 121:1958.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Osteoprotegerin/TNFRSF ...
MAB8051
Osteoprotegerin/TNFRSF11B Antibody (69127) [Unconjugated]
Species: Hu
Applications: ELISA(Cap)

Publications for Osteoprotegerin/TNFRSF11B Antibody (MAB8051)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Antibody Array Development, ELISA Development, ELISA Development (Capture), IHC-P.


Filter By Application
Antibody Array Development
(1)
ELISA Development
(2)
ELISA Development (Capture)
(1)
IHC-P
(1)
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Human
(5)
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Showing Publications 1 - 8 of 8.
Publications using MAB8051 Applications Species
S Giovannini, G Tinelli, F Biscetti, G Straface, F Angelini, D Pitocco, L Mucci, R Landolfi, A Flex Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects Cardiovasc Diabetol, 2017-08-08;16(1):99. 2017-08-08 [PMID: 28789654] (ELISA Development (Capture), Human) ELISA Development (Capture) Human
Kis Djamiatun, Andre J. A. M. van der Ven, Philip G. de Groot, Sultana M. H. Faradz, D. Hapsari, Wil M. V. Dolmans et al. Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13 PLoS Neglected Tropical Diseases 2012-05-01 [PMID: 22563509]
Yiwen Liu, Tao Wang, Jianyun Yan, Naomi Jiagbogu, Daniëlle A.M. Heideman, Ann E. Canfield et al. HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro Atherosclerosis 2011-12-01 [PMID: 21920521]
Irene Zinonos, Agatha Labrinidis, Michelle Lee, Vasilios Liapis, Shelley Hay, Vladimir Ponomarev et al. Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo Journal of Bone and Mineral Research 2017-07-29 [PMID: 20818644]
Hu H, Kwun J, Aizenstein BD, Knechtle SJ Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation, 2009-06-27;87(12):1814-20. 2009-06-27 [PMID: 19543058] (Antibody Array Development, Human) Antibody Array Development Human
Harding G, Mak YT, Evans B, Cheung J, MacDonald D, Hampson G The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA. Cytokine, 2006-12-11;36(1):57-68. 2006-12-11 [PMID: 17161616] (ELISA Development, Human) ELISA Development Human
Cross SS, Yang Z, Brown NJ, Balasubramanian SP, Evans CA, Woodward JK, Neville-Webbe HL, Lippitt JM, Reed MW, Coleman RE, Holen I Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int. J. Cancer, 2006-04-15;118(8):1901-8. 2006-04-15 [PMID: 16287088] (IHC-P, Human) IHC-P Human
Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J. Rheumatol., 2005-04-01;32(4):713-20. 2005-04-01 [PMID: 15801030] (ELISA Development, Human) ELISA Development Human

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Bioinformatics

Gene Symbol TNFRSF11B
Uniprot