Oct-4A Antibody (653108) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Oct-3/4, alternately Oct-3 or Oct-4, is POU5F1 (POU domain containing, class 5, transcription factor 1), a 360 amino acid (aa) transcription factor that is expressed in totipotent embryonic stem and germ cells. The human Oct-4, Oct-3/4 or POU5F1 gene can be transcribed into at least three transcripts (Oct-4A, Oct-4B, and Oct-4B1) and generates four protein isoforms by alternative splicing and alternative translation initiation. Oct-4A expression is restricted to embryonic stem (ES) and embryonic carcinoma (EC) cells and is believed to be the transcription factor responsible for the pluripotency properties of embryonic stem (ES) cells. In contrast, Oct-4B/4B1 can be detected in various nonpluripotent cell types and cannot sustain ES cell pluripotency and self-renewal.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, ICC, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using MAB17591	Applications	Species
Mann, JR;McKenna, ED;Mawrie, D;Papakis, V;Alessandrini, F;Anderson, EN;Mayers, R;Ball, HE;Kaspi, E;Lubinski, K;Baron, DM;Tellez, L;Landers, JE;Pandey, UB;Kiskinis, E; Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import Science advances 2023-08-18 [PMID: 37585529] (ICC, Human)	ICC	Human
Funes, S;Gadd, DH;Mosqueda, M;Zhong, J;Jung, J;Shankaracharya, ;Unger, M;Cameron, D;Dawes, P;Keagle, PJ;McDonough, JA;Boopathy, S;Sena-Esteves, M;Lutz, C;Skarnes, WC;Lim, ET;Schafer, DP;Massi, F;Landers, JE;Bosco, DA; Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia bioRxiv : the preprint server for biology 2023-06-01 [PMID: 37398081] (ICC, Human)	ICC	Human
DM Baron, AR Fenton, S Saez-Atien, A Giampetruz, A Sreeram, Shankarach, PJ Keagle, VR Doocy, NJ Smith, EW Danielson, M Andresano, MC McCormack, J Garcia, V Bercier, L Van Den Bo, JR Brent, C Fallini, BJ Traynor, ELF Holzbaur, JE Landers ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function Cell Reports, 2022-04-05;39(1):110598. 4/5/2022 [PMID: 35385738]
YC Lin, MS Kumar, N Ramesh, EN Anderson, AT Nguyen, B Kim, S Cheung, JA McDonough, WC Skarnes, R Lopez-Gonz, JE Landers, NL Fawzi, IRA Mackenzie, EB Lee, JA Nickerson, D Grunwald, UB Pandey, DA Bosco Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway Nature Neuroscience, 2021-05-31;0(0):. 2021-05-31 [PMID: 34059832] (ICC, Human)	ICC	Human
F Vlahova, KE Hawkins, AM Ranzoni, KL Hau, R Sagar, P Coppi, AL David, J Adjaye, PV Guillot Human mid-trimester amniotic fluid (stem) cells lack expression of the pluripotency marker OCT4A Sci Rep, 2019-05-31;9(1):8126. 2019-05-31 [PMID: 31148575] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Genome-Wide Transcriptome and Binding Sites Analyses Identify Early FOX Expressions for Enhancing Cardiomyogenesis Efficiency of hESC Cultures Sci Rep, 2016-08-09;6(0):31068. 2016-08-09 [PMID: 27501774] (Flow Cytometry, Human)	Flow Cytometry	Human
Laura E. Sidney, Matthew J. Branch, Harminder S. Dua, Andrew Hopkinson Effect of culture medium on propagation and phenotype of corneal stroma–derived stem cells Cytotherapy 2015-12-01 [PMID: 26454751]
Liying Zhang, Jing Guo, Pengyuan Zhang, Qiang Xiong, Steven C. Wu, Lily Xia et al. Derivation and High Engraftment of Patient-Specific Cardiomyocyte Sheet Using Induced Pluripotent Stem Cells Generated From Adult Cardiac Fibroblast Circulation: Heart Failure 2015-01-01 [PMID: 25420485]

Array MAB17591

• Oct-4A Antibodies