Recombinant Mouse Noggin Protein

Noggin encoded by the NOG gene, was first isolated from Xenopus, having the function of inducing secondary axis formation in frog embryos. It inhibits TGF-beta family ligands and preventing them from binding to their corresponding receptors. Noggin was originally found as a BMP-4 antagonist, and then has been shown to modulate the activities of other BMPs (BMP-2, 7, 13 and 14). Additionally, it has pleiotropic effect, both in early development and later stages. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. In recent report, proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have relation with the mutant of evolutionarily conserved amino acid residues of Noggin. Mature mouse Noggin shares 99% and 83% a.a. sequence identity with human and Xenopus Noggin, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Porcine.

Showing Publications 1 - 2 of 2.

Publications using NBP2-35098	Applications	Species
AD Werts, WB Fulton, MR Ladd, A Saad-Eldin, YX Chen, ML Kovler, H Jia, EC Banfield, R Buck, K Goerhing, T Prindle, S Wang, Q Zhou, P Lu, Y Yamaguchi, CP Sodhi, DJ Hackam A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis Cell Mol Gastroenterol Hepatol, 2019-11-19;0(0):. 2019-11-19 [PMID: 31756560]
Ladd MR, Martin LY, Werts A et al. The Development of Newborn Porcine Models for Evaluation of Tissue Engineered Small Intestine. Tissue Eng Part C Methods 2018-04-11 [PMID: 29638197] (Porcine)		Porcine

Array NBP2-35098

• Noggin Antibodies
• Noggin ELISA Kit
• Noggin Lysate
• Noggin Proteins
• Noggin Proteins and Enzymes