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NKX3.1 Antibody (0361) [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IP, KD
Clone
0361
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-1828AF350
Alexa Fluor 405
NB100-1828AF405
Alexa Fluor 488
NB100-1828AF488
Alexa Fluor 532
NB100-1828AF532
Alexa Fluor 594
NB100-1828AF594
Alexa Fluor 647
NB100-1828AF647
Alexa Fluor 700
NB100-1828AF700
Alexa Fluor 750
NB100-1828AF750
Allophycocyanin
NB100-1828APC
Biotin
NB100-1828B
CoraFluor 1
NB100-1828CL1
DyLight 350
NB100-1828UV
DyLight 488
NB100-1828G
DyLight 550
NB100-1828R
DyLight 594
NB100-1828DL594
DyLight 650
NB100-1828C
DyLight 680
NB100-1828FR
DyLight 755
NB100-1828IR
FITC
NB100-1828F
HRP
NB100-1828H
Janelia Fluor 525
NB100-1828JF525
Janelia Fluor 549
NB100-1828JF549
Janelia Fluor 646
NB100-1828JF646
Janelia Fluor 669
NB100-1828JF669
PE
NB100-1828PE
PerCP
NB100-1828PCP
Unconjugated
NB100-1828
mFluor Violet 450 SE
NB100-1828MFV450
mFluor Violet 500 SE
NB100-1828MFV500
mFluor Violet 610 SE
NB100-1828MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB100-1828
BSA Free
NB100-1828SS
BSA Free
NB100-1828
Azide and BSA Free
NBP2-80880
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NKX3.1 Antibody (0361) [DyLight 405] Summary

Immunogen
Full-length human Nkx3.1 produced in bacteria as a hexahistidine-tagged protein. [UniProt# Q99801]
Localization
Nuclear
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
NKX3-1
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted to work in human based on 100% sequence homology. Human reactivity reported in scientific literature (PMID: 22465996).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for NKX3.1 Antibody (0361) [DyLight 405]

  • BAPX2
  • BAPX2homeobox protein Nkx-3.1
  • Homeobox protein NK-3 homolog A
  • NK homeobox (Drosophila), family 3, A
  • NK3 homeobox 1
  • NK3 transcription factor homolog A
  • NK3 transcription factor related, locus 1 (Drosophila)
  • NK3 transcription factor related, locus 1
  • NKX3.1
  • NKX3.1NKX3
  • NKX3-1
  • NKX3A
  • NKX3ANK homeobox, family 3, A

Background

NKX3.1 (homeobox protein Nkx-3.1) is a homeodomain nuclear transcription factor expressed predominately in the prostate with very low testicular expression and is highly important in prostate biology. NKX3.1 interacts with SRF, SPDEF, WDR77 etc. and TOPORS polyubiquitinates NKX3-1 for inducing its proteasomal degradation regulation. NKX3.1 binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and act as a transcriptional repressor for playing important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Additionally, NKX3.1 functions as a prostate-specific tumor suppressor and diminished NKX3.1 expression is a consistent feature in human/mouse prostate cancers, wherein its expression is lost early in tumorigenesis suggesting that NKX3.1 loss is an early step in the progression to malignant disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NKX3-1