NGFR/TNFRSF16/p75NTR Antibody (2F1C2) - BSA Free

p75NTR/NGF Receptor, also known as Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. p75NTR/NGF Receptor plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of p75NTR/NGF Receptor by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to p75NTR/NGF Receptor activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-51590

• NGFR/TNFRSF16/p75NTR Antibodies
• NGFR/TNFRSF16/p75NTR Lysate
• NGFR/TNFRSF16/p75NTR Proteins
• NGFR/TNFRSF16/p75NTR Proteins and Enzymes
• NGFR/TNFRSF16/p75NTR ELISAs