Neprilysin/CD10 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neprilysin/CD10, also known as NEP and neutral endopeptidase 24.11, is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The enzyme functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide (1, 2). NEP has also been identified as the common acute lymphocytic leukemia antigen (CALLA), and is expressed on the surface of lymphocytes in some disease states (3, 4). These and other observations have resulted in considerable interest in NEP as a target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid beta  peptide (A beta ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting A beta accumulation (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Activity Assay, ELISA Development, ICC, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using AF1182	Applications	Species
Fitzgerald G, Turiel G, Gorski T et al. MME(+) fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle Communications Biology 2023-01-27 [PMID: 36707617]
Shan Li, Guo-Ji Yan, Ya-Xin Tan, Lu-Lu Xue, Ting-Hua Wang, Hao-Ran Zhao et al. Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by A beta 1-42 Neural Plasticity 2022-11-10 [PMID: 36406589]
T Turunen, M Magris, M Malinen, J Kekäläinen Seminal-Plasma-Mediated Effects on Sperm Performance in Humans Cells, 2022-07-08;11(14):. 2022-07-08 [PMID: 35883590] (Western Blot, Human)	Western Blot	Human
T Hu, SS Li, MN Lu, L Zhang, B Chen, R Mao, R Mei, YX Tan, S Li, YB Xiyang Neuroprotection induced by Navbeta2?knockdown in APP/PS1 transgenic neurons is associated with NEP regulation Mol Med Rep, 2019-06-20;20(2):2002-2011. 2019-06-20 [PMID: 31257483] (Activity Assay, Mouse)	Activity Assay	Mouse
MOW Grimm, A Thiel, AA Lauer, J Winkler, J Lehmann, L Regner, C Nelke, D Janitschke, C Benoist, O Streidenbe, H Stötzel, K Endres, C Herr, C Beisswenge, HS Grimm, R Bals, F Lammert, T Hartmann Vitamin D and Its Analogues Decrease Amyloid-? (A?) Formation and Increase A?-Degradation Int J Mol Sci, 2017-12-19;18(12):. 2017-12-19 [PMID: 29257109] (Activity Assay, Mouse)	Activity Assay	Mouse
Marcus O. W. Grimm, Janine Mett, Christoph P. Stahlmann, Sven Grösgen, Viola J. Haupenthal, Tamara Blümel et al. APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression Frontiers in Aging Neuroscience 2015-05-19 [PMID: 26074811]
Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J. Immunol., 2011-05-06;186(12):6925-32. 2011-05-06 [PMID: 21551363] (ELISA Development, ICC, Human)	ELISA Development, ICC	Human
Danielyan L, Schafer R, Schulz A, Ladewig T, Lourhmati A, Buadze M, Schmitt AL, Verleysdonk S, Kabisch D, Koeppen K, Siegel G, Proksch B, Kluba T, Eckert A, Kohle C, Schoneberg T, Northoff H, Schwab M, Gleiter CH Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin. Cell Death Differ., 2009-07-17;16(12):1599-614. 2009-07-17 [PMID: 19609278] (Western Blot, Human)	Western Blot	Human

Array AF1182

• Neprilysin/CD10 Antibodies
• Neprilysin/CD10 ELISA Kit
• Neprilysin/CD10 Lysates
• Neprilysin/CD10 Proteins
• Neprilysin/CD10 Proteins and Enzymes
• Neprilysin/CD10 ELISAs