NEDD4 Antibody

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. NEDD4 contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/kDFR, independently of its ubiquitin-ligase activity. NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence, NEDD4 acts as down regulator of Notch-1 gene expression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-27197

• NEDD4 Antibodies
• NEDD4 Lysate
• NEDD4 Protein
• NEDD4 Proteins and Enzyme