Myosin heavy chain 11 Antibody (JA03-35)

The protein encoded by the MYH11 gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. MYH11 functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 2 of 2.

Publications using NBP2-66967	Applications	Species
Lin CJ, Mecham RP Tissue-specific smooth muscle cell subtypes identified by transcriptional profiling The international journal of biochemistry & cell biology 2021-08-16 [PMID: 34411694] (ICC/IF, Mouse)	ICC/IF	Mouse
Lin CJ, Staiculescu MC, Hawes JZ et al. Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development Circ. Res. 2019-10-08 [PMID: 31590613]

Array NBP2-66967

• Myosin heavy chain 11 Antibodies
• Myosin heavy chain 11 Proteins