MRGX2 Antibody

FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: FLOW, ICC/IF, IHC-P, KD, WB.

Showing Publications 1 - 8 of 8.

Publications using NB110-75035	Applications	Species
Sun X, Lv W, Wang Y et al. Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection Journal of ethnopharmacology 2022-01-29 [PMID: 35104575] (WB, Mouse)	WB	Mouse
Widner DB, Liu C, Zhao Q et al. Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia Journal of cachexia, sarcopenia and muscle 2021-05-18 [PMID: 34008339] (WB, Mouse)	WB	Mouse
Idahosa, CN The Mast Cell Receptor Mas-Related Gene X2 (MrgX2) in Health and Disease. Thesis. 2015-11-01 (ICC/IF, IHC-P, Human)	ICC/IF, IHC-P	Human
Alkanfari, I;Freeman, KB;Roy, S;Jahan, T;Scott, RW;Ali, H; Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs Cells 2019-04-03 [PMID: 30987258] (WB, Human)	WB	Human
Roy S, Ganguly A, Haque M, Ali H. Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells. J. Immunol. 2019-01-16 [PMID: 30651343] (WB, Human)	WB	Human
Subramanian H, Gupta K, Lee D et al. beta-Defensins Activate Human Mast Cells via Mas-Related Gene X2. J Immunol 2013-07-01 [PMID: 23698749] (WB, Human)	WB	Human
Alkanfari IS The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function Thesis (WB, FLOW, KD, Human, Mouse)	WB, FLOW, KD	Human, Mouse
Callahan BN, Kammala AK, Syed M et al. Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses Front Immunol 2020-04-24 [PMID: 32391014] (ICC/IF, Human) Details: Confocal microscopy	ICC/IF	Human

Array NB110-75035

• MRGX2 Antibodies
• MRGX2 Protein