Mouse Phospho-Tie-2 DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 3 of 3.

Publications using DYC2816-2	Applications	Species
Lin, Y;McClennan, A;Hoffman, L; Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice Biomedicines 2023-08-14 [PMID: 37626761] (Mouse)		Mouse
NV Bogatcheva, ME Coleman Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice Cells, 2021-03-24;10(4):. 2021-03-24 [PMID: 33804896] (Mouse)		Mouse
B Gutbier, X Jiang, K Dietert, C Ehrler, J Lienau, P Van Slyke, H Kim, VC Hoang, JT Maynes, DJ Dumont, AD Gruber, N Weissmann, TJ Mitchell, N Suttorp, M Witzenrath Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia Crit Care, 2017-11-13;21(1):274. 2017-11-13 [PMID: 29132435] (Mouse)		Mouse

Array DYC2816-2

• Tie-2 Antibodies
• Tie-2 Antibody Pair
• Tie-2 Lysate
• Tie-2 Protein
• Tie-2 ELISAs
• Tie-2 Proteins and Enzymes