Immunohistochemistry-Paraffin: MDR3/ABCB4 Antibody [NBP2-30876] - Staining of human skeletal muscle shows no positivity in myocytes as exected.
Immunohistochemistry-Paraffin: MDR3/ABCB4 Antibody [NBP2-30876] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: MDR3/ABCB4 Antibody [NBP2-30876] - Staining of human liver shows weak to moderate membranous positivity in bile duct cells.
Immunohistochemistry-Paraffin: MDR3/ABCB4 Antibody [NBP2-30876] - Staining of human placenta shows no positivity in trophoblastic cells as expected.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for MDR3/ABCB4 Antibody
ABC21
ABCB4
ATP-binding cassette sub-family B member 4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
EC 3.6.3
EC 3.6.3.44
GBD1
MDR2
MDR3
MDR3MDR2/3
multidrug resistance protein 3
multiple drug resistance 3
P glycoprotein 3/multiple drug resistance 3
PFIC-3
P-glycoprotein 3
P-glycoprotein-3/multiple drug resistance-3
PGY3
PGY3GBD1
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. (provided by RefSeq)
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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