MBP Antibody (2H9) - BSA Free

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: FLOW, IF/IHC, IHC-P, In vivo assay.

Showing Publications 1 - 6 of 6.

Publications using NBP2-22121	Applications	Species
Linnerbauer M, Beyer T, Nirschl L et al. PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation Nat Commun 2023-09-09 [PMID: 37689786]
Holloway RK, Zhang L, Molina-Gonzalez I et al. Localized microglia dysregulation impairs central nervous system myelination in development Acta neuropathologica communications 2023-03-22 [PMID: 36949514] (IHC-P, Human)	IHC-P	Human
Linnerbauer M, L��lein L, Farrenkopf D et al. Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation Frontiers in Immunology 2022-01-03 [PMID: 35046956] (In vivo assay)	In vivo assay
Ruhela D, Bhopale VM, Kalakonda S et al. Astrocyte-derived microparticles initiate a neuroinflammatory cycle due to carbon monoxide poisoning Brain Behav Immun Health 2021-12-01 [PMID: 34917988] (FLOW, Mouse)	FLOW	Mouse
Mozafari S, Starost L, Manot-Saillet B, Garcia-Diaz B Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo Sci Adv 2020-12-05 [PMID: 33277253]
Schmitt C, Lechanteur A, Cossais F et al. Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices International Journal of Nanomedicine 2020-05-25 [PMID: 32547020] (IF/IHC, Mouse)	IF/IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-Fr	Mouse	05/09/2019	View Summary Application Immunohistochemistry-Frozen Sample Tested Mouse brain Species Mouse Lot A1
Enlarge	4 reviewed by: Jan Martinek	Immunofluorescence Frozen Acetone fixed	Mouse	12/07/2018	View Summary Application Other Sample Tested Mouse brain Species Mouse Lot A-1

Array NBP2-22121

• MBP Antibodies
• MBP ELISA Kits
• MBP Lysates
• MBP Proteins
• MBP ELISA