MBD4 Antibody

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Chemotaxis, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-24393	Applications	Species
Ruddock-D'Cruz NT, Xue J, Wilson KJ et al. Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. Mol Reprod Dev. 2008-01-01 [PMID: 17546630] (WB, Mouse) Details: IF [bovine embryos (Fig 3) and mouse embryos (Fig 4)] and for WB [bovine heart, (supplementary data)] 1. MBD1 mAb (IMG-306) 2. MBD3/MBD2 mAb (IMG-296A) 3. MBD4 pAb (IMG-285).	WB	Mouse
Thatcher KN, Peddada S, Yasui DH, Lasalle JM. Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet. 2005-03-15 [PMID: 15689352] (Chemotaxis) Details: ChIP (Fig 6): SH-SY5Y cells	Chemotaxis

Array NBP2-24393

• MBD4 Antibodies
• MBD4 Proteins