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Lysosomal Pro-X Carboxypeptidase/PRCP Antibody

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Western Blot: Lysosomal Pro-X Carboxypeptidase/PRCP Antibody [H00005547-D01P] - Analysis of PRCP expression in transfected 293T cell line by PRCP polyclonal antibody.Lane 1: PRCP transfected lysate(55.80 KDa).Lane 2: ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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Lysosomal Pro-X Carboxypeptidase/PRCP Antibody Summary

Description
Quality control test: Antibody reactive against mammalian transfected lysate.
Immunogen
PRCP (NP_005031.1, 1 a.a. - 496 a.a.) full-length human protein. MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
Specificity
Reacts with prolylcarboxypeptidase (angiotensinase C).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PRCP
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This antibody is reactive against transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Lysosomal Pro-X Carboxypeptidase/PRCP Antibody

  • Angiotensinase C
  • EC 3.4.16.2
  • HUMPCP
  • Lysosomal carboxypeptidase C
  • lysosomal Pro-X carboxypeptidase
  • PCPMGC2202
  • PRCP
  • Proline carboxypeptidase
  • prolylcarboxypeptidase (angiotensinase C)
  • prolylcarboxypeptidase isoform 1 preproprotein
  • Prolylcarboxypeptidase

Background

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PRCP
Entrez
Uniprot