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LSD1 Antibody [CoraFluor™ 1]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Ca, Pm, ZeSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-56475AF350
Alexa Fluor 405
NB100-56475AF405
Alexa Fluor 488
NB100-56475AF488
Alexa Fluor 532
NB100-56475AF532
Alexa Fluor 594
NB100-56475AF594
Alexa Fluor 647
NB100-56475AF647
Alexa Fluor 700
NB100-56475AF700
Alexa Fluor 750
NB100-56475AF750
Allophycocyanin
NB100-56475APC
Biotin
NB100-56475B
DyLight 350
NB100-56475UV
DyLight 405
NB100-56475V
DyLight 488
NB100-56475G
DyLight 550
NB100-56475R
DyLight 594
NB100-56475DL594
DyLight 650
NB100-56475C
DyLight 680
NB100-56475FR
DyLight 755
NB100-56475IR
FITC
NB100-56475F
HRP
NB100-56475H
Janelia Fluor 525
NB100-56475JF525
Janelia Fluor 549
NB100-56475JF549
Janelia Fluor 585
NB100-56475JF585
Janelia Fluor 635
NB100-56475JF635
Janelia Fluor 646
NB100-56475JF646
Janelia Fluor 669
NB100-56475JF669
PE
NB100-56475PE
PerCP
NB100-56475PCP
Unconjugated
NB100-56475
mFluor Violet 450 SE
NB100-56475MFV450
mFluor Violet 500 SE
NB100-56475MFV500
mFluor Violet 610 SE
NB100-56475MFV610
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LSD1 Antibody [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
A portion of amino acids 100-150 of human LSD1 was used as the immunogen.
Marker
Nucleus Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KDM1A
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for LSD1 Antibody [CoraFluor™ 1]

  • amine oxidase (flavin containing) domain 2
  • AOF2
  • AOF2lysine-specific histone demethylase 1
  • BHC110
  • BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
  • Flavin-containing amine oxidase domain-containing protein 2
  • KIAA0601KDM1
  • LSD1
  • LSD1BRAF35-HDAC complex protein BHC110
  • lysine (K)-specific demethylase 1
  • Lysine (K)specific Demethylase 1A
  • Lysine (K)-specific Demethylase 1A
  • lysine-specific histone demethylase 1A

Background

LSD1 a recently identified, first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KDM1A