Species: Hu, Mu, Pm
Applications: WB, Simple Western, ELISA, IHC, ChIP, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Ca, Pm, Ze
Applications: WB
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: Func
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
LSD1 a recently identified, first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
23028 |
| Alternate Names |
- amine oxidase (flavin containing) domain 2
- AOF2lysine-specific histone demethylase 1
- BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
- Flavin-containing amine oxidase domain-containing protein 2
- KIAA0601KDM1
- LSD1BRAF35-HDAC complex protein BHC110
- lysine (K)-specific demethylase 1
- lysine (K)-specific demethylase 1A
- lysine-specific histone demethylase 1A
|
