LMO2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LMO2, also known as Rhombotin-2 and T-cell translocation protein-2, is a transcriptional co‑factor that is required for hematopoietic and endothelial development. It contains two LIM domains that are characterized by a zinc binding, cysteine rich motif consisting of two tandemly repeated zinc fingers. LMO2 does not interact directly with DNA but is involved in the assembly of multiprotein transcription factor complexes. Human and mouse LMO2 share 99% amino acid sequence homology.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ChIP, ChIP-Seq, Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using AF2726	Applications	Species
Courtney Chambers, Katerina Cermakova, Yuen San Chan, Kristen Kurtz, Katharina Wohlan, Andrew Henry Lewis et al. SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia Cancer Research 2023-04-04 [PMID: 36662812]
KI Hirano, H Hosokawa, M Koizumi, Y Endo, T Yahata, K Ando, K Hozumi LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice Elife, 2021-08-12;10(0):. 2021-08-12 [PMID: 34382935] (ChIP, Mouse)	ChIP	Mouse
N Bery, CJR Bataille, A Russell, A Hayes, F Raynaud, S Milhas, S Anand, H Tulmin, A Miller, TH Rabbitts A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2 Science Advances, 2021-04-09;7(15):. 2021-04-09 [PMID: 33837087] (Western Blot, Human)	Western Blot	Human
M Nafria, P Keane, ES Ng, EG Stanley, AG Elefanty, C Bonifer Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells Cell Rep, 2020-05-26;31(8):107691. 2020-05-26 [PMID: 32460028] (ChIP-Seq, Human)	ChIP-Seq	Human
LiQi Li, Apratim Mitra, Kairong Cui, Bin Zhao, Seeyoung Choi, Jan Y. Lee et al. Ldb1 is required for Lmo2 oncogene–induced thymocyte self-renewal and T-cell acute lymphoblastic leukemia Blood 2020-06-18 [PMID: 32181817]
VS Stanulovic, P Cauchy, SA Assi, M Hoogenkamp LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage Nucleic Acids Res., 2017-09-29;45(17):9874-9888. 2017-09-29 [PMID: 28973433] (Western Blot, Mouse)	Western Blot	Mouse
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors Nat Commun, 2016-11-21;7(0):13396. 2016-11-21 [PMID: 27869129] (Human)		Human
Carolina A Braghini, Flavia C Costa, Halyna Fedosyuk, Renee Y Neades, Lesya V Novikova, Matthew P Parker et al. Original Research: Generation of non-deletional hereditary persistence of fetal hemoglobin beta -globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH Experimental Biology and Medicine 2016-04-01 [PMID: 26946532]
Krivega I, Byrnes C, de Vasconcellos J, Lee Y, Kaushal M, Dean A, Miller J Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/gamma-globin looping. Blood, 2015-05-15;126(5):665-72. 5/15/2015 [PMID: 25979948]
Beeke Wienert, Alister P. W. Funnell, Laura J. Norton, Richard C. M. Pearson, Lorna E. Wilkinson-White, Krystal Lester et al. Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin Nature Communications 2015-05-14 [PMID: 25971621]
Anetta Ptasinska, Salam A. Assi, Natalia Martinez-Soria, Maria Rosaria Imperato, Jason Piper, Pierre Cauchy et al. Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal Cell Reports 2014-09-25 [PMID: 25242324]
Treanor L, Zhou S, Janke L, Churchman M, Ma Z, Lu T, Chen S, Mullighan C, Sorrentino B Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med, 2014-03-31;211(4):701-13. 2014-03-31 [PMID: 24687960] (Western Blot, Mouse)	Western Blot	Mouse
Won Ju Yun, Yea Woon Kim, Yujin Kang, Jungbae Lee, Ann Dean, AeRi Kim The hematopoietic regulator TAL1 is required for chromatin looping between the beta -globin LCR and human gamma -globin genes to activate transcription Nucleic Acids Research 2014-04-01 [PMID: 24470145]
Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Gottgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood, 2010-06-02;116(6):962-70. 2010-06-02 [PMID: 20519628] (Western Blot, Human)	Western Blot	Human
Eduardo Anguita, Ana Villegas, Francisco Iborra, Aurora Hernandez GFI1B controls its own expression binding to multiple sites Haematologica 2010-01-01 [PMID: 19773260]
Show All 15 Publications. Collapse Publications.

Array AF2726

• LMO2 Antibodies
• LMO2 Lysates
• LMO2 Proteins