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Laforin/EPM2A Antibody (523435)

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Western blot shows lysates of human heart and brain tissue, and HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL Mouse Anti-Human Laforin/EPM2A Monoclonal Antibody (Catalog # ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
523435
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price
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Laforin/EPM2A Antibody (523435) Summary

Immunogen
E. coli-derived recombinant human Laforin/EPM2A
Met1-Leu331
Accession # AAH70047
Specificity
Detects human Laforin/EPM2A in Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
EPM2A
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Laforin/EPM2A Antibody (523435)

  • EC 3.1.3.16
  • EC 3.1.3.48
  • epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
  • epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
  • EPM2
  • EPM2A
  • Lafora PTPase
  • Laforin
  • LAFPTPase
  • LD
  • LDE
  • MELF

Background

Laforin, also known as Lafora PTPase and EPM2A, is a 38 kDa member of the protein tyrosine phosphatase family. Human Laforin is 331 aa in length and contains one carbohydrate binding type-20 (CBM20) domain (aa 1-124) and one tyrosine-protein phosphatase domain (aa 243-311). Multiple splicing variants produce four isoforms of human Laforin, which is most highly expressed in heart, skeletal muscle, kidney, pancreas and brain. It functions as a dual specificity protein phosphatase and may be involved in the control of glycogen metabolism. Mutations in Laforin cause progressive myoclonic epilepsy type 2, also known as Lafora disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Laforin/EPM2A Antibody (MAB5714) (0)

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Bioinformatics

Gene Symbol EPM2A
Uniprot