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L1CAM Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining in human cerebral cortex and skeletal muscle tissues.. Corresponding L1CAM RNA-seq data are presented for the same ...read more
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuropil.
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human kidney shows moderate membranous positivity in cells in distal tubules.
Immunohistochemistry-Paraffin: L1CAM Antibody [NBP1-86544] - Staining of human colon shows moderate positivity in peripheral nerve / ganglion.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

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L1CAM Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: ELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATE
Marker
Axon Marker
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
L1CAM
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
L1CAM Protein (NBP1-86544PEP)
Publications
Read Publication using NBP1-86544.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25862471).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for L1CAM Antibody

  • antigen identified by monoclonal R1
  • CAML1
  • CAML1N-CAML1
  • CD171 antigen
  • CD171
  • HSAS
  • HSAS1
  • L1 cell adhesion molecule
  • L1CAM
  • MASA
  • MIC5
  • N-CAM-L1
  • NCAM-L1
  • neural cell adhesion molecule L1
  • S10
  • SPG1

Background

The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for L1CAM Antibody (NBP1-86544)(1)

We have publications tested in 1 confirmed species: Human.


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Secondary Antibodies

 

Isotype Controls

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Research Areas for L1CAM Antibody (NBP1-86544)

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Blogs on L1CAM.

Identifying tumoral and stromal transcriptomes that underlie tumor plasticity and stromal neuroinflammatory response in brain metastasis
By Jamshed Arslan, Pharm. D., PhD. Cancers in the brain often come from tumors elsewhere in the body. Several adaptive mechanisms influence brain metastasis, such as blood brain barrier leakage that can be induced by ...  Read full blog post.

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Bioinformatics

Gene Symbol L1CAM