Western blot shows lysates of mouse liver tissue, rat spleen tissue, and MDA-MB-453 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Rabbit Anti-Human/Mouse/Rat Kynurenine 3-Monooxygenase/KMO ...read more
Kynurenine 3-Monooxygenase/KMO was detected in immersion fixed paraffin-embedded sections of human placenta using Rabbit Anti-Human/Mouse/Rat Kynurenine 3-Monooxygenase/KMO Monoclonal Antibody (Catalog # MAB8050) ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Kynurenine 3-Monooxygenase/KMO Antibody (2493A) [Unconjugated]
Kynurenine 3-Monooxygenase (KMO), also known as Kynurenine 3-Hydroxylase, is a part of the kynurenine pathway of tryptophan degradation (1). KMO catalyzes the NADPH- and flavin adenine dinucleotide (FAD)-dependent 3-hydroxylation of kynurenine to 3-hydroxykynurenine (3-HK). 3-HK is neurotoxic via the generation of hydrogen peroxide (2) and through the excitotoxic effects of its downstream metabolite quinolinic acid (3). The levels of 3-HK and quinolinic acid are increased in the brain with Alzheimer's disease and Huntington's disease (1). Inhibition of KMO was shown to reverse cognitive and motor deficits in mouse models of those diseases via an increase in neuroprotective kynurenic acid (4). KMO is found in the mitochondrial outer membrane of microglial cells in the brain and dendritic cells and macrophages in the periphery (1).
Schwarcz, R. et al. (2012) Nat. Rev. Neurosci. 13:465.
Okuda, S. et al. (1996) Proc. Natl. Acad. Sci. 93:12553.
Stone, T.W. and M.N. Perkins. (1981) Eur. J. Pharmacol. 72:411.
Zwilling, D. et al. (2011) Cell 145:863.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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