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KLHDC2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: KLHDC2 Antibody [NBP2-14163] - Immunofluorescent staining of human cell line RH-30 shows localization to nuclear bodies & nuclear membrane.
Immunohistochemistry-Paraffin: KLHDC2 Antibody [NBP2-14163] -Staining of human prostate shows moderate nuclear/nuclear membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: KLHDC2 Antibody [NBP2-14163] -Staining of human fallopian tube shows moderate nuclear/nuclear membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: KLHDC2 Antibody [NBP2-14163] -Staining of human testis shows moderate nuclear/nuclear membranous positivity in Leydig cells and cells in seminiferous ducts.
Immunohistochemistry-Paraffin: KLHDC2 Antibody [NBP2-14163] - Staining of human kidney shows moderate nuclear/nuclear membranous positivity in cells in tubules.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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KLHDC2 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the amino acids: MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKL
Predicted Species
Mouse (96%), Rat (96%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KLHDC2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF,Fixation Permeabilization: Use PFA/Triton X-100.
Control Peptide
KLHDC2 Protein (NBP2-14163PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for KLHDC2 Antibody

  • HCA33
  • HCLP-1Host cell factor-like protein 1
  • Hepatocellular carcinoma-associated antigen 33
  • Host cell factor homolog LCP
  • kelch domain containing 2
  • kelch domain-containing protein 2
  • KLHDC2
  • LCP

Background

KLHDC2, also known as Kelch domain-containing protein 2, is a 46kDa 406 amino acid protein with a shorter 28kDa 249 isoform produced by alternative splicing. KLHDC2 interfers with CREB3-DNA binding by repressing CREB3-mediated transcription. Current research is being conducted on KLHDC2 in relation to Legg-Calve-Perthes disease, hepatocellular carcinoma and herpes simplex. KLHDC2 is linked to the reflex, excretion, micturition, cytokine production and lactation pathways where it interacts with DDX19B, SFN, STRN4, EZH2 and UBXN7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KLHDC2