KAT3B/p300 Antibody (RW128) - BSA Free

In eukaryotic genome, the chromatin dynamicity is crucial for regulation of processes requiring access to genetic information and it is regulated by several different factors including post-translational modifications of histone/non-histone components, especially via acetylation process which is catalyzed by enzymes known as lysine acetyltransferases (KATs). Among different KATs, KAT3B/ p300 and its homologue KAT3A/CBP (CREB-binding protein) are extensively studied KATs with well known cellular functions. KAT3B/ p300 and KAT3A/CBP have been shown to directly interact with several different DNA-binding transcription factors which includes nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Moreover, both KAT3B/p300 and KAT3A/CBP have been shown to exert HAT (histone acetyltransferase) activity, capable of acetylating all four core histone particles in nucleosomes and to play a key role in activating chromatin for transcription. KAT3B/p300 is a potent transcriptional coactivator that has been shown to regulate various biological processes such as cellular proliferation, differentiation, cell cycle, apoptosis, and response to genetic damage, and KAT3B/ p300 dysfunction interfering with these processes implicates in the pathogenesis of several diseases such as cancer, cardiac diseases, diabetes mellitus, and HIV.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-507	Applications	Species
Paladino David, Yue Peibin, Furuya Hideki et al. A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget 2016-01-01 [PMID: 26695438] (WB, Human)	WB	Human
Kung A L, Zabludoff S D et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 2004-01-07 [PMID: 15261140] (WB, Human)	WB	Human
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev;13(1):64-75. 1999-01-01 [PMID: 9887100]
Nemethova M, Wintersberger E. Polyomavirus large T antigen binds the transcriptional coactivator protein p300. J Virol;73(2):1734-9. 1999-02-01 [PMID: 9882390]
Eckner R et al. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev;1 (19):2478-90. 1996-10-01 [PMID: 8843199]
Eckner R et al. Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol;16(7):3454-64. 1996-07-01 [PMID: 8668161] (IP, Mouse)	IP	Mouse
Eckner R et al. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev;8(8):869-84. 1994-04-15 [PMID: 7523245]

Array NB100-507

• KAT3B/p300 Antibodies
• KAT3B/p300 ELISA Kits
• KAT3B/p300 Proteins